• Publications
  • Influence
Induction of phase I, II and III drug metabolism/transport by xenobiotics
TLDR
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs introduced into the human body, and play crucial roles in response to many polycyclic aromatic hydrocarbon receptors and excretion. Expand
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
TLDR
The results showed that ARE activation and Nrf2 protein accumulation were well correlated with phase II gene expression induction, and the structure-activity relationship study indicated that the third sulfur in the structure of OSCs contributed substantially to their bioactivities, and that allyl-containing O SCs were more potent than propyl- containing OSCS. Expand
Antioxidants and oxidants regulated signal transduction pathways.
TLDR
A model is proposed, that at low concentrations, these compounds activate MAPK pathway leading to activation of Nrf2 and ARE with subsequent induction of phase II and other defensive genes which protect cells against toxic insults thereby enhancing cell survival, a beneficial homeostatic response. Expand
Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE),†,‡
TLDR
A model is proposed where these xenobiotics activate the MAPK pathway via an electrophilic-mediated stress response, leading to the transcription activation of Nrf2/Maf heterodimers on ARE/EpRE enhancers, with the subsequent induction of cellular defense/detoxifying genes including Phase II DMEs, which may protect the cells against toxic environmental insults and thereby enhance cell survival. Expand
Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates*
TLDR
It is reported that phenylmethyl isocyacyanate and phenylethyl isothiocyanates induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner and that PMITC and PEITC may have chemotherapeutic functions besides their chemopreventive functions. Expand
Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects.
  • Chi Chen, A. Kong
  • Biology, Medicine
  • Trends in pharmacological sciences
  • 1 June 2005
TLDR
Current knowledge on dietary cancer-chemopreventive compounds and their induction of detoxifying enzymes and anti-proliferative effects are summarized, and the challenges in translating these signaling and gene-expression events to pharmacological effects are discussed. Expand
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
TLDR
To better understand the pharmacogenomic/gene expression profile of DMEs and the underlying molecular mechanisms after exposure to xenobiotics or drugs, cDNA microarray or oligonucleotide-based DNA chip technology can be a powerful tool to analyze, simultaneously, the gene expression profiles that are induced or repressed by Xenobiotics. Expand
Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism*
  • R. Yu, C. Chen, +4 authors A. Kong
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 22 December 2000
TLDR
MAP kinase pathways that are activated by MEKK1, TAK1, and ASK1 may link chemical signals to Nrf2, leading to the activation of ARE-dependent genes. Expand
Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.
TLDR
The current understanding of the Nrf2/ARE pathway as a potential molecular target for cancer chemoprevention is discussed, as well as the feasibility of screening natural compounds for activation of this pathway and as potential cancer preventive agents for human use are discussed. Expand
Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals*
  • Rong Yu, Wei Lei, +4 authors A. Kong
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 24 September 1999
TLDR
The results indicate that the induction of ARE-dependent phase II detoxifying enzymes is mediated by a MAPK pathway, which may involve direct activation of Raf-1 by the inducers. Expand
...
1
2
3
4
5
...