Share This Author
Induction of phase I, II and III drug metabolism/transport by xenobiotics
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs introduced into the human body, and play crucial roles in response to many polycyclic aromatic hydrocarbon receptors and excretion.
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals.
Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE),†,‡
- A. Kong, E. Owuor, S. Mandlekar
- Biology, ChemistryDrug metabolism reviews (Softcover ed.)
- 1 January 2001
A model is proposed where these xenobiotics activate the MAPK pathway via an electrophilic-mediated stress response, leading to the transcription activation of Nrf2/Maf heterodimers on ARE/EpRE enhancers, with the subsequent induction of cellular defense/detoxifying genes including Phase II DMEs, which may protect the cells against toxic environmental insults and thereby enhance cell survival.
Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates*
- Yi-Rong Chen, Wenfu Wang, A. Kong, T. Tan
- Biology, ChemistryJournal of Biological Chemistry
- 16 January 1998
It is reported that phenylmethyl isocyacyanate and phenylethyl isothiocyanates induced sustained c-Jun N-terminal kinase (JNK) activation in a dose-dependent manner and that PMITC and PEITC may have chemotherapeutic functions besides their chemopreventive functions.
Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects.
Antioxidants and oxidants regulated signal transduction pathways.
Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals*
The results indicate that the induction of ARE-dependent phase II detoxifying enzymes is mediated by a MAPK pathway, which may involve direct activation of Raf-1 by the inducers.
Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism*
MAP kinase pathways that are activated by MEKK1, TAK1, and ASK1 may link chemical signals to Nrf2, leading to the activation of ARE-dependent genes.
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes.
To better understand the pharmacogenomic/gene expression profile of DMEs and the underlying molecular mechanisms after exposure to xenobiotics or drugs, cDNA microarray or oligonucleotide-based DNA chip technology can be a powerful tool to analyze, simultaneously, the gene expression profiles that are induced or repressed by Xenobiotics.
Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.
The current understanding of the Nrf2/ARE pathway as a potential molecular target for cancer chemoprevention is discussed, as well as the feasibility of screening natural compounds for activation of this pathway and as potential cancer preventive agents for human use are discussed.