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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
TLDR
The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
TLDR
This investigation expands the horizon of Nrf2-regulated genes, highlights the cross-talk between various metabolic pathways, and divulges the pivotal role played by NRF2 in regulating cellular defenses against carcinogens and other toxins.
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.
TLDR
The responsiveness of the Nrf2 pathway may act as a major determinant of susceptibility to tobacco smoke-induced emphysema by upregulating antioxidant defenses and decreasing lung inflammation and alveolar cell apoptosis.
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
TLDR
Evidence for formation of intermolecular disulfide bridges was obtained by 2D PAGE of extracts of cells treated with inducers, and by the demonstration that whereas C273A and C288A mutants of Keap1 alone could not repress Nrf2 activation of the ARE-luciferase reporter, an equal mixture of these mutant constructs restored repressor activity.
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
TLDR
Nrf2 is revealed as a novel modifier gene of sepsis that determines survival by mounting an appropriate innate immune response by regulating cellular glutathione and other antioxidants is critical for optimal NF-kappaB activation in response to LPS and TNF-alpha.
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
TLDR
This review describes historical milestones in the initial characterization of the KEAP1-NRF2 system and provides a comprehensive overview of the molecular mechanisms governing the functions ofKEAP1 and NRF2, as well as their roles in physiology and pathology.
Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
TLDR
The unique biological properties of Mox macrophages suggest this phenotype may play an important role in atherosclerotic lesion development as well as in other settings of chronic inflammation.
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
TLDR
This study reveals global circuitry of the NRF2 stress response emphasizing Nrf2 as a central node in cell survival response and modulated pathways in stress response and cell proliferation distinguish the inducible and basal programs.
Role of NRF2 in protection against hyperoxic lung injury in mice.
TLDR
It is demonstrated that NRF2 has a significant protective role against pulmonary hyperoxic injury in mice, possibly through transcriptional activation of lung antioxidant defense enzymes.
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
TLDR
An overview of the physiological and pathological roles of NRF2 is provided, emerging pharmacological modulators of theNRF2–KEAP1 axis are presented and associated drug development challenges are highlighted.
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