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The chemical diversity and distribution of glucosinolates and isothiocyanates among plants.
Glucosinolates (beta-thioglucoside-N-hydroxysulfates), the precursors of isothiocyanates, are present in sixteen families of dicotyledonous angiosperms including a large number of edible species. AtExpand
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Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Part 1.
Moringa oleifera, or the horseradish tree, is a pan-tropical species that is known by such regional names as benzolive, drumstick tree, kelor, marango, mlonge, mulangay, nebeday, saijhan, and sajna.Expand
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  • Open Access
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protectionExpand
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  • Open Access
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables.
Isothiocyanates and their naturally occurring glucosinolate precursors are widely consumed as part of a diet rich in cruciferous vegetables. When plant cells are damaged, glucosinolates are releasedExpand
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  • Open Access
Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.
Broccoli sprouts are a rich source of glucosinolates and isothiocyanates that induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer.Expand
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  • Open Access
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
Gastric infection with Helicobacter pylori is a cosmopolitan problem, and is especially common in developing regions where there is also a high prevalence of gastric cancer. These infections areExpand
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Chemoprotection against cancer by phase 2 enzyme induction.
Mammalian cells have evolved elaborate mechanisms for protection against the toxic and neoplastic effects of electrophilic metabolites of carcinogens and reactive oxygen species. Phase 2 enzymesExpand
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Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism.
Several epidemiologic studies suggest that consumption of cruciferous vegetables may be particularly effective (compared with total fruit and vegetable consumption) in reducing cancer risk at severalExpand
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Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
  • J. Fahey, P. Talalay
  • Medicine, Chemistry
  • Food and chemical toxicology : an international…
  • 1 September 1999
The widespread belief that oxidative damage plays a major role in cancer, ageing, and in a number of chronic diseases has focused scienti®c and public attention on the possibility that antioxidantsExpand
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  • Open Access
Sulforaphane treatment of autism spectrum disorder (ASD)
Significance Autism spectrum disorder (ASD), encompassing impaired communication and social interaction, and repetitive stereotypic behavior and language, affects 1–2% of predominantly maleExpand
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  • Open Access