Isothiocyanates

Known as: Isothiocyanates [Chemical/Ingredient], isothiocyanate 
Organic compounds with the general formula R-NCS.
National Institutes of Health

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1,3,6-trisulfonylpyrene 8-isothiocyanate1,4-phenylene diisothiocyanate10-isothiocyano-4-cadinene2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate
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In Bloodagonistsantagonists & inhibitorschemical synthesis

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Sulfur Compounds

Papers overview

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Highly Cited
2006
Highly Cited
2006
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.
Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability, and their increase in cancer cells is… (More)
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Highly Cited
2004
Highly Cited
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl… (More)
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Highly Cited
2001
Highly Cited
2001
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.
The natural indoles 3,3'-diindolylmethane (DIM), ascorbigen (ASG), indole-3-carbinol (I3C), and indolo[3,2-b]carbazole (ICZ), as… (More)
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Highly Cited
2000
Highly Cited
2000
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China
BACKGROUND Dietary isothiocyanates inhibit lung carcinogenesis in laboratory animals but human data are limited. Glutathione S… (More)
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Review
1999
Review
1999
Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
Substantial quantities of isothiocyanates are released upon consumption of normal amounts of a number of cruciferous vegetables… (More)
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Highly Cited
1998
Highly Cited
1998
Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.
Isothiocyanates exert strong anticarcinogenic effects in a number of animal models of cancer, presumably by modulation of… (More)
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Highly Cited
1998
Highly Cited
1998
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables.
Isothiocyanates and their naturally occurring glucosinolate precursors are widely consumed as part of a diet rich in cruciferous… (More)
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Review
1995
Review
1995
Chemoprevention by isothiocyanates.
Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of… (More)
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Highly Cited
1995
Highly Cited
1995
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.
The catalytic properties of four human glutathione transferases (GSTs), A1-1, M1-1, M4-4 and P1-1, were examined with 14… (More)
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Review
1994
Review
1994
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms.
Organic isothiocyanates block the production of tumors induced in rodents by diverse carcinogens (polycyclic aromatic… (More)
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