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A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.
TLDR
A cohort of 18,244 mostly middle-aged (45-64 years) men residing in four small geographically defined areas of Shanghai was accrued between January 1986 and September 1989 and the extent of aflatoxin exposure in the study population was quantitatively estimated.
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Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.
TLDR
Aflatoxin biomarkers of internal and biologically effective doses have been integral to the establishment of the etiologic role of this toxin in human disease through better estimates of exposure, expanded knowledge of the mechanisms of disease pathogenesis, and as tools for implementing and evaluating preventive interventions.
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Workgroup Report: Public Health Strategies for Reducing Aflatoxin Exposure in Developing Countries
TLDR
A workgroup of international experts and health officials convened in Geneva, Switzerland, in July 2005 identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies.
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SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
TLDR
The high prevalence of the aberrant SOCS-1 methylation and its growth suppression activity demonstrated the importance of the constitutive activation of the JAK/STAT pathway in the development of HCC.
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Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma
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DNA damage by mycotoxins.
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Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in The Gambia, West Africa.
TLDR
The validity of aflatoxin-albumin adducts as a marker of human exposure to this carcinogen is demonstrated and matched chronic hepatitis B surface antigen carriers with noncarriers did not reveal any difference in adduct formation.
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Translational strategies for cancer prevention in liver
TLDR
Targeted chemoprevention might be most appropriate for the present generation of individuals at risk of liver cancer and may require considerable investment of time and resources.
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Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
TLDR
This study highlights the feasibility of inducing phase 2 enzymes as a chemopreventive strategy in humans and inhibited phase 1 activation of aflatoxins, and sustained low-dose oltipraz increased phase 2 conjugation of a Flatoxin, yielding higher levels of a flatoxin-mercapturic acid.
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Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China.
TLDR
The relationship between dietary intake of aflatoxins and the excretion of the major aflatoxin-DNA adduct and other metabolites into the urine of chronically exposed people was explored and there was no positive statistical association between exposure in the diet and a flatoxin P1 excretion, despite aflat toxin P1 being quantitatively a major metabolite.
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