stress-induced premature senescence

Known as: SIPS 
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
05010019542016

Papers overview

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Review
2018
Review
2018
Stress, cell senescence and organismal ageing
  • João Pedro de Magalhães, João F. Passos
  • Mechanisms of Ageing and Development
  • 2018
Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the irreversible arrest of cells following… (More)
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2012
2012
Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence.
Stress-induced premature senescence (SIPS) of endothelial cells (ECs) has emerged as a contributor to global EC dysfunction. One… (More)
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Highly Cited
2009
Highly Cited
2009
Alterations in microRNA expression in stress-induced cellular senescence.
We investigated miRNA expression changes associated with stress-induced premature senescence (SIPS) in primary cultures of human… (More)
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2008
2008
Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
INTRODUCTION Chronic and debilitating low back pain is a common condition and a huge economic burden. Many cases are attributed… (More)
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Highly Cited
2007
Highly Cited
2007
Sirt1 modulates premature senescence-like phenotype in human endothelial cells.
Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian Sirt1 NAD(+)-dependent protein… (More)
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Highly Cited
2005
Highly Cited
2005
Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway.
Premature senescence of human diploid fibroblasts (HDFs) can be induced by exposures to a variety of oxidative stress and DNA… (More)
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2004
2004
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
In addition to replicative senescence, normal diploid fibroblasts undergo stress-induced premature senescence (SIPS) in response… (More)
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Highly Cited
2002
Highly Cited
2002
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.
Cells subjected to sub-lethal doses of stress such as irradiation or oxidative damage enter a state that closely resembles… (More)
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2002
2002
Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence.
Exposure of human proliferative cells to subcytotoxic stress triggers stress-induced premature senescence (SIPS) which is… (More)
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Highly Cited
1977
Highly Cited
1977
Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis.
Significant differences in both specificity and avidity of anti-DNA antibodies were observed in the sera of groups of patients… (More)
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