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Identification of a New Acute Phase Protein (*)
It is shown that the SIP24/24P3 protein and mRNA increase dramatically in mouse serum and liver during the acute phase response induced by turpentine injection, and it is concluded that SIP20/20P3 is a new type 1 acute phase protein.
Mathematical modeling of capillary formation and development in tumor angiogenesis: Penetration into the stroma
A mathematical model for the tumor vascularization theory of tumor growth proposed by Judah Folkman in the early 1970s and subsequently established experimentally by him and his coworkers is presented and very good computational agreement with the time of vascularization and the rate of capillary tip growth observed in rabbit cornea experiments is obtained.
Mathematical modeling of the onset of capillary formation initiating angiogenesis
A new approach to angiogenesis is presented, based on the theory of reinforced random walks, coupled with a Michaelis-Menten type mechanism which views the endothelial cell receptors as the catalyst for transforming angiogenic factor into proteolytic enzyme in order to model the first stage.
A mathematical model for the roles of pericytes and macrophages in the initiation of angiogenesis. I. The role of protease inhibitors in preventing angiogenesis.
Protein‐Mediated Synthesis of Uniform Superparamagnetic Magnetite Nanocrystals
Magnetite nanocrystals are synthesized in the presence of a recombinant Mms6 protein thought to be involved in the biomineralization of bacterial magnetite magnetosomes, the mammalian iron‐storage…
Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres.
ICGA-PSO-ELM Approach for Accurate Multiclass Cancer Classification Resulting in Reduced Gene Sets in Which Genes Encoding Secreted Proteins Are Highly Represented
- S. Saraswathi, S. Sundaram, N. Sundararajan, Michael T. Zimmermann, M. Nilsen-Hamilton
- Computer Science, BiologyIEEE/ACM Transactions on Computational Biology…
- 1 March 2011
The genes identified by this study that encode secreted proteins might provide important insights to the nature of the critical biological features in the microenvironment of each tumor type that allow these cells to thrive and proliferate.
Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver.
Astrocyte‐derived interleukin‐6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus
- Jisun Oh, M. McCloskey, Christopher C. Blong, L. Bendickson, M. Nilsen-Hamilton, D. Sakaguchi
- BiologyJournal of neuroscience research
- 1 October 2010
The results suggest that astrocyte‐derived IL‐6 may facilitate AHPC neuronal differentiation and have important implications for understanding injury‐induced neurogenesis and developing cell‐based therapeutic strategies using neural progenitors.
Effects of dexamethazone on LPS‐induced activationand migration of mouse dendritic cells revealed by a genome‐wide transcriptional analysis
- C. Vizzardelli, N. Pavelka, P. Ricciardi-Castagnoli
- Biology, MedicineEuropean journal of immunology
- 1 June 2006
A genome‐wide analysis of differentially expressed genes of DC treated with Dex alone, LPS alone, or both, using high‐density oligonucleotide microarrays observed a synergistic effect of Dex and LPS on the expression of the secreted lipocalin 24p3, which has been reported to induce apoptosis in T cells and thus may be related to immune suppression.