R. T. Hamilton

Publications52
h-index20
Citations1,251
Highly Influential Citations11
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Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.
TLDR
A good positive correlation between the extent of ras expression, the metastatic potential, and the amount of the secreted protease was found in nine independently isolated lines.
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Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
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Selective stimulation by mitogens of incorporation of 35S-methionine into a family of proteins released into the medium by 3T3 cells
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Regulation of guanylate and adenylate cyclase activities by lysolecithin.
The guanylate cyclase activity [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] in membrane preparations from 3T3 mouse fibroblasts is stimulated approximately 5-fold by lysolecithin at…
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Basic fibroblast growth factor induces 3T3 fibroblasts to synthesize and secrete a cyclophilin-like protein and β2-microglobulin
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Developmental expression of cathepsin L and c‐rasHa in the mouse placenta
TLDR
The presence of large amounts of cathepsin L in the placenta suggests that the proteinase has a significant function there and is potentially under the control of the ras gene product p21; both are under developmental control.
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Signaling between the Placenta and the Uterus Involving the Mitogen-Regulated Protein/Proliferins1.
TLDR
The results are consistent with the hypothesis that MRP/PLFs stimulate uterine proliferation in vivo and that a uterine factor shuts off PLF1 and/or MRP3 synthesis in the latter half of gestation.
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Mrp4, a new mitogen-regulated protein/proliferin gene; unique in this gene family for its expression in the adult mouse tail and ear.
TLDR
Unique among the members of the mrp/plf family for its expression in the hair follicles of the tail and ear, MRP4 is expected to have a singular role in the growth and development of these follicles.
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Superinduction by cycloheximide of mitogen‐induced secreted proteins produced by Balb/c 3T3 cells
TLDR
The characteristics of the regulation of a group of secretory proteins whose secreted levels rise within 2–4 h of adding fibroblast growth factor, epidermal growth factors, or serum to quiescent Balb/c 3T3 cells are described.
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Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.
TLDR
The amino acid sequence of a part of the murine major excreted protein deduced from the DNA sequence reveals substantial and significant homology with the cysteine proteases actinidin, rat cathepsin H, and papain.
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