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Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.
A good positive correlation between the extent of ras expression, the metastatic potential, and the amount of the secreted protease was found in nine independently isolated lines.
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
Selective stimulation by mitogens of incorporation of 35S-methionine into a family of proteins released into the medium by 3T3 cells
Regulation of guanylate and adenylate cyclase activities by lysolecithin.
- W. Shier, J. H. Baldwin, M. Nilsen-Hamilton, R. T. Hamilton, N. Thanassi
- BiologyProceedings of the National Academy of Sciences…
- 1 May 1976
The guanylate cyclase activity [GTP pyrophosphate-lyase (cyclizing), EC 18.104.22.168] in membrane preparations from 3T3 mouse fibroblasts is stimulated approximately 5-fold by lysolecithin at…
Basic fibroblast growth factor induces 3T3 fibroblasts to synthesize and secrete a cyclophilin-like protein and β2-microglobulin
Developmental expression of cathepsin L and c‐rasHa in the mouse placenta
- R. T. Hamilton, K. Bruns, M. Nilsen-Hamilton
- BiologyMolecular reproduction and development
- 1 December 1991
The presence of large amounts of cathepsin L in the placenta suggests that the proteinase has a significant function there and is potentially under the control of the ras gene product p21; both are under developmental control.
Signaling between the Placenta and the Uterus Involving the Mitogen-Regulated Protein/Proliferins1.
The results are consistent with the hypothesis that MRP/PLFs stimulate uterine proliferation in vivo and that a uterine factor shuts off PLF1 and/or MRP3 synthesis in the latter half of gestation.
Mrp4, a new mitogen-regulated protein/proliferin gene; unique in this gene family for its expression in the adult mouse tail and ear.
Unique among the members of the mrp/plf family for its expression in the hair follicles of the tail and ear, MRP4 is expected to have a singular role in the growth and development of these follicles.
Superinduction by cycloheximide of mitogen‐induced secreted proteins produced by Balb/c 3T3 cells
The characteristics of the regulation of a group of secretory proteins whose secreted levels rise within 2–4 h of adding fibroblast growth factor, epidermal growth factors, or serum to quiescent Balb/c 3T3 cells are described.
Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.
The amino acid sequence of a part of the murine major excreted protein deduced from the DNA sequence reveals substantial and significant homology with the cysteine proteases actinidin, rat cathepsin H, and papain.