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Signal Peptide-Dependent Protein Transport inBacillus subtilis: a Genome-Based Survey of the Secretome
SUMMARY One of the most salient features of Bacillus subtilis and related bacilli is their natural capacity to secrete a variety of proteins into their environment, frequently to high concentrations.Expand
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Cancer has long been considered a genetic disease. However, accumulating evidence supports the involvement of infectious agents in the development of cancer, especially in those organs that areExpand
Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome
SUMMARY Secretory proteins perform a variety of important“ remote-control” functions for bacterial survival in the environment. The availability of complete genome sequences has allowed us to makeExpand
A proteomic view on genome-based signal peptide predictions.
The availability of complete genome sequences has allowed the prediction of all exported proteins of the corresponding organisms with dedicated algorithms. Even though numerous studies report onExpand
Towards the Human Colorectal Cancer Microbiome
Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with disease initiation and progression.Expand
Type I signal peptidases of Gram-positive bacteria.
Proteins that are exported from the cytoplasm to the periplasm and outer membrane of Gram-negative bacteria, or the cell wall and growth medium of Gram-positive bacteria, are generally synthesized asExpand
Bacillus subtilis Contains Four Closely Related Type I Signal Peptidases with Overlapping Substrate Specificities
Most biological membranes contain one or two type I signal peptidases for the removal of signal peptides from secretory precursor proteins. In this respect, the Gram-positive bacteriumBacillusExpand
The Role of Lipoprotein Processing by Signal Peptidase II in the Gram-positive Eubacterium Bacillus subtilis
Computer-assisted analyses indicate thatBacillus subtilis contains approximately 300 genes for exported proteins with an amino-terminal signal peptide. About 114 of these are lipoproteins, which areExpand
Novel clues on the specific association of Streptococcus gallolyticus subsp gallolyticus with colorectal cancer.
BACKGROUND The prevalence of Streptococcus gallolyticus subsp gallolyticus ( Streptococcus bovis biotype I) endocarditis is in general low but very often linked to colorectal cancer. Therefore, thisExpand
The effects of acute exercise bouts on hepcidin in women.
PURPOSE To investigate the effects of acute exercise on serum hepcidin and iron (sFe) in active women. Changes in interleukin-6 (IL-6), hepcidin, ferritin, and sFe in response to 2 different exerciseExpand