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streptolydigin

 
National Institutes of Health

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2009
2009
The biosynthetic gene cluster for the dienoyltetramic acid streptolydigin was identified and characterized from the producer… Expand
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Highly Cited
2007
Highly Cited
2007
The mechanism of substrate loading in multisubunit RNA polymerase is crucial for understanding the general principles of… Expand
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Highly Cited
2005
Highly Cited
2005
We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid… Expand
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Highly Cited
2005
Highly Cited
2005
Streptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs). The 2.4 A resolution structure of the Thermus… Expand
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Highly Cited
1993
Highly Cited
1993
Mutations to rifampicin resistance (RifR) in Escherichia coli alter the beta subunit of RNA polymerase (RNAP). A series of new… Expand
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Highly Cited
1980
Highly Cited
1980
The similarity of the morphology and of DNA composition, the homology of the component patterns of DNA-dependent RNA polymerases… Expand
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Highly Cited
1978
Highly Cited
1978
A new bacteriophage, MX4, was isolated from nature and tested for transduction in strains of Myxococcus xanthus. The phage shows… Expand
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1971
1971
The antibiotic streptolydigin inhibits RNA polymerase by reducing the rate of RNA chain growth. It does not affect the fidelity… Expand
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1969
1969
THE RNA polymerase of Escherichia coli consists of two small subunits α, two larger subunits β and β′, and one subunit σ which… Expand
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1969
1969
Streptolydigin and rifamycin inhibit the catalytic function of ribonucleic acid (RNA) polymerase. Streptolydigin can inhibit… Expand
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