streptolydigin

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
051019542016

Papers overview

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2011
2011
The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic… (More)
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2009
2009
The biosynthetic gene cluster for the dienoyltetramic acid streptolydigin was identified and characterized from the producer… (More)
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Highly Cited
2007
Highly Cited
2007
The mechanism of substrate loading in multisubunit RNA polymerase is crucial for understanding the general principles of… (More)
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2005
2005
Streptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs). The 2.4 A resolution structure of the Thermus… (More)
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Highly Cited
2005
Highly Cited
2005
We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid… (More)
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2004
2004
[reaction: see text] Isotope labeling studies show that malonate, not acetate, furnishes all four C(2) units in the acyltetramic… (More)
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Highly Cited
1993
Highly Cited
1993
Mutations to rifampicin resistance (RifR) in Escherichia coli alter the beta subunit of RNA polymerase (RNAP). A series of new… (More)
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1993
1993
Streptolydigin (stl), a bacteriostatic inhibitor of transcription elongation, interacts with the beta subunit of Escherichia coli… (More)
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1980
1980
The mechanism of streptolydigin inhibition of RNA synthesis has been investigated with a combination of steady state kinetics and… (More)
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1969
1969
Streptolydigin and rifamycin inhibit the catalytic function of ribonucleic acid (RNA) polymerase. Streptolydigin can inhibit… (More)
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