streptolydigin

The biosynthetic gene cluster for the dienoyltetramic acid streptolydigin was identified and characterized from the producer… Expand

The mechanism of substrate loading in multisubunit RNA polymerase is crucial for understanding the general principles of… Expand

We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid… Expand

Streptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs). The 2.4 A resolution structure of the Thermus… Expand

Mutations to rifampicin resistance (RifR) in Escherichia coli alter the beta subunit of RNA polymerase (RNAP). A series of new… Expand

Abstract A new bacteriophage, MX4, was isolated from nature and tested for transduction in strains of Myxococcus xanthus. The… Expand

The chromosomes of Escherichia coli 15T− and a streptolydigin-sensitive mutant, 15T− lyd-4, were aligned by amino-acid starvation… Expand

The antibiotic streptolydigin inhibits RNA polymerase by reducing the rate of RNA chain growth. It does not affect the fidelity… Expand

THE RNA polymerase of Escherichia coli consists of two small subunits α, two larger subunits β and β′, and one subunit σ which… Expand

Streptolydigin and rifamycin inhibit the catalytic function of ribonucleic acid (RNA) polymerase. Streptolydigin can inhibit… Expand