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streptolydigin

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
051019542016

Related topics

Related topics

2 relations

Broader (1)

Aminoglycosides
Antibiotics

Related mentions per year

Related mentions per year

1942-2018
19401960198020002020
streptolydigin
Antibiotics
Aminoglycosides

Papers overview

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2011
2011
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.
The asparaginyl-tRNA synthetase-like SlgZ and methyltransferase SlgM enzymes are involved in the biosynthesis of the tetramic… (More)
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2009
2009
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.
The biosynthetic gene cluster for the dienoyltetramic acid streptolydigin was identified and characterized from the producer… (More)
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Highly Cited
2007
Highly Cited
2007
Structural basis for substrate loading in bacterial RNA polymerase.
The mechanism of substrate loading in multisubunit RNA polymerase is crucial for understanding the general principles of… (More)
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2005
2005
Structural basis of transcription inhibition by antibiotic streptolydigin.
Streptolydigin (Stl) is a potent inhibitor of bacterial RNA polymerases (RNAPs). The 2.4 A resolution structure of the Thermus… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibition of Bacterial RNA Polymerase by Streptolydigin: Stabilization of a Straight-Bridge-Helix Active-Center Conformation
We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid… (More)
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2004
2004
Investigation of the origin of C2 units in biosynthesis of streptolydigin.
[reaction: see text] Isotope labeling studies show that malonate, not acetate, furnishes all four C(2) units in the acyltetramic… (More)
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Highly Cited
1993
Highly Cited
1993
Rifampicin region revisited. New rifampicin-resistant and streptolydigin-resistant mutants in the beta subunit of Escherichia coli RNA polymerase.
Mutations to rifampicin resistance (RifR) in Escherichia coli alter the beta subunit of RNA polymerase (RNAP). A series of new… (More)
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1993
1993
Four contiguous amino acids define the target for streptolydigin resistance in the beta subunit of Escherichia coli RNA polymerase.
Streptolydigin (stl), a bacteriostatic inhibitor of transcription elongation, interacts with the beta subunit of Escherichia coli… (More)
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1980
1980
On the mechanism of streptolydigin inhibition of Escherichia coli RNA polymerase.
The mechanism of streptolydigin inhibition of RNA synthesis has been investigated with a combination of steady state kinetics and… (More)
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1969
1969
Mode of action of streptolydigin.
Streptolydigin and rifamycin inhibit the catalytic function of ribonucleic acid (RNA) polymerase. Streptolydigin can inhibit… (More)
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