A. Kornberg

Publications497
h-index108
Citations36,906
Highly Influential Citations1,145
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Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa.
Polyphosphate kinase (PPK), encoded by the ppk gene, is the principal enzyme in many bacteria for the synthesis of inorganic polyphosphate (poly P) from ATP. A knockout mutant in the ppk gene of… Expand
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Inorganic polyphosphate: essential for growth and survival.
Inorganic polyphosphate (Poly P) is a polymer of tens to hundreds of phosphate residues linked by "high-energy" phosphoanhydride bonds as in ATP. Found in abundance in all cells in nature, it is… Expand
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Inorganic polyphosphate: a molecule of many functions.
Inorganic polyphosphate (poly P) is a chain of tens or many hundreds of phosphate (Pi) residues linked by high-energy phosphoanhydride bonds. Despite inorganic polyphosphate's ubiquity--found in… Expand
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Inorganic polyphosphate: a molecule of many functions.
  • A. Kornberg
  • Chemistry, Biology
  • Progress in molecular and subcellular biology
  • 28 November 2003
Pursuit of the enzymes that make and degrade polyP has provided analytic reagents which confirm the ubiquity of polyP in microbes and animals and provide reliable means for measuring very low… Expand
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Inorganic polyphosphate: toward making a forgotten polymer unforgettable.
  • A. Kornberg
  • Biology, Medicine
  • Journal of bacteriology
  • 1 February 1995
Pursuit of the enzymes that make and degrade poly P has provided analytic reagents which confirm the ubiquity of poly P in microbes and animals and provide reliable means for measuring very low… Expand
  • 474
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Novel assay reveals multiple pathways regulating stress-induced accumulations of inorganic polyphosphate in Escherichia coli.
A major impediment to understanding the biological roles of inorganic polyphosphate (polyP) has been the lack of sensitive definitive methods to extract and quantitate cellular polyP. We show that… Expand
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The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate.
The discovery of carbon dioxide assimilation by heterotrophic bacteria (1) and animal tissues (2) aroused considerable interest in the mechanisms involved. Evidence from various sources suggested the… Expand
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ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome
ATP is bound to dnaA protein with high affinity (KD = 0.03 microM) and hydrolyzed slowly to ADP in the presence of DNA. ADP is also bound tightly to dnaA protein and exchanges with ATP very slowly.… Expand
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A polyphosphate kinase (PPK2) widely conserved in bacteria
Synthesis of inorganic polyphosphate (poly P) from the terminal phosphate of ATP is catalyzed reversibly by poly P kinase (PPK, now designated PPK1) initially isolated from Escherichia coli. PPK1 is… Expand
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The dnaA protein complex with the E. coli chromosomal replication origin (oriC) and other DNA sites
Specific binding of dnaA protein to the E. coli origin of replication (oriC) is essential for initiation of chromosomal replication. Based on binding of plasmid DNA fragments, dnaA protein recognizes… Expand
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