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Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa.
TLDR
A knockout mutant in the ppk gene of Pseudomonas aeruginosa PAO1 is impaired in flagellar swimming motility on semisolid agar plates, revealing important roles for poly P in diverse processes such as biofilm formation, symbiosis, and virulence.
Inorganic polyphosphate: essential for growth and survival.
TLDR
There is extensive evidence that the remarkable properties of Poly P as a polyanion have made it suited for a crucial role in the emergence of cells on earth, and this review pays particular attention to the enzyme, polyphosphate kinase 1, responsible for Poly P synthesis and highly conserved in many bacterial species, including 20 or more of the major pathogens.
Inorganic polyphosphate: a molecule of many functions.
  • A. Kornberg
  • Chemistry, Biology
    Progress in molecular and subcellular biology
  • 28 November 2003
TLDR
Of theoretical interest regarding polyP is its antiquity in prebiotic evolution, which, along with its high energy and phosphate content, make it a plausible precursor to RNA, DNA and proteins, and its many industrial applications, including its use in the microbial depollution of Pi in marine environments.
Inorganic polyphosphate: toward making a forgotten polymer unforgettable
  • A. Kornberg
  • Medicine, Biology
    Journal of bacteriology
  • 1 February 1995
TLDR
It would be surprising if some of the variety of poly P functions observed in microorganisms did not apply to aspects of human growth and development, such as aging and the aberrations of disease.
Inorganic polyphosphate: a molecule of many functions.
TLDR
This review focuses on recent advances made possible by the introduction of novel, enzymatically based assays that provide highly specific, sensitive, and facile assays adaptable to a high-throughput format on inorganic polyphosphate.
The dnaA protein complex with the E. coli chromosomal replication origin (oriC) and other DNA sites
TLDR
DnaA protein recognizes in addition to oriC a number of specific sites: within or near the replication origins of pSC101, pBR322, and ColE1; within the regulatory regions of the dnaA and "X-protein" genes; and in IRL-Tn5.
Novel Assay Reveals Multiple Pathways Regulating Stress-Induced Accumulations of Inorganic Polyphosphate in Escherichia coli
TLDR
It is found that bacteria subjected to nutritional or osmotic stress in a rich medium or to nitrogen exhaustion had large and dynamic accumulations of polyP, and analysis of Escherichia coli mutants revealed that polyP accumulation depends on several regulatory genes, glnD, rpoS, relA, and phoB.
The enzymatic mechanism of oxidation-reductions between malate or isocitrate and pyruvate.
TLDR
The discovery of carbon dioxide assimilation by heterotrophic bacteria and animal tissues aroused considerable interest in the mechanisms involved and Evans, Vennesland, and Slotin discovered that pigeon liver extracts fixed in the presence of malate, pyruvate, and catalytic amounts of manganous ions and of either diphosphopyridine nucleotide (DPN) or triphosphoyridineucleotide (TPN), while catalyzing the overall Reaction 1.
ATP activates dnaA protein in initiating replication of plasmids bearing the origin of the E. coli chromosome
TLDR
The extraordinary affinity of ATP for dnaA protein, its slow hydrolysis to ADP, the profound inhibition of dnaB protein functions by ADp, and the very slow exchange of ADP all point to a possible regulatory role for these nucleotides in the cell cycle.
Duplex opening by dnaA protein at novel sequences in initiation of replication at the origin of the E. coli chromosome
TLDR
It is proposed that dnaA protein recognizes and successively opens the 13-mer sequences, thereby guiding the entry of dnaB helicase into the duplex preparatory to priming of replication.
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