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squalestatin 1

Known as: zaragozic acid A 
National Institutes of Health

Related topics

Related topics

6 relations
7-deoxy zaragozic acid

Broader (5)

Anticholesteremic AgentsAntifungal AgentsBridged Bicyclo Compounds, HeterocyclicEnzyme Inhibitors

Papers overview

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2016
2016
Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming
The complete stereochemical course and substrate selectivity of the enoyl reductase domain from the fungal polyketide synthase… 
2008
2008
Inhibition of squalene synthase upregulates PCSK9 expression in rat liver.
Highly Cited
2002
Highly Cited
2002
Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor.
Because our previous studies indicated that squalestatin 1 treatment induces CYP2B expression in primary cultures of rat… 
1999
1999
HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured…
The activity of HMG-CoA reductase (HMGR) is tightly regulated, in part through post-transcriptional mechanisms that are mediated… 
Highly Cited
1998
Highly Cited
1998
Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A.
The zaragozic acids are potent inhibitors of squalene synthase. In vivo studies in mice confirmed our earlier observations that… 
1998
1998
Influence of water activity and temperature on in vitro growth of surface cultures of a Phoma sp. and production of the pharmaceutical metabolites, squalestatins S1 and S2
Abstract A Phoma sp., known to produce the pharmaceutically active metabolites squalestatin 1 (S1) and squalestatin 2 (S2), was… 
1995
1995
Selective Inhibition of Cholesterol Biosynthesis in Brain Cells by Squalestatin 1
Abstract: The effect of squalestatin 1 (SQ) on squalene synthase and other enzymes utilizing farnesyl pyrophosphate (F‐P‐P) as… 
Highly Cited
1995
Highly Cited
1995
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.
Evidence has been obtained indicating that free farnesol (F-OH) can be utilized for isoprenoid biosynthesis in mammalian cells… 
Highly Cited
1993
Highly Cited
1993
Competitive inhibition of squalene synthetase by squalestatin 1.
synthetase (EC 2.5.1.21) is a microsomal enzyme which catalyzes the two sequential reactions: head-to-head condensation of… 
1993
1993
The asymmetric syntheses of the C-1 sidechains of zaragozic acid A and zaragozic acid C
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