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squalestatin 1

Known as: zaragozic acid A 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Farnesyl pyrophosphate (FPP), a key intermediate in the mevalonate pathway and protein farnesylation, can act as an agonist for… Expand
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2008
2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in cholesterol metabolism by enhancing the… Expand
Highly Cited
2002
Highly Cited
2002
Because our previous studies indicated that squalestatin 1 treatment induces CYP2B expression in primary cultures of rat… Expand
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1999
1999
The activity of HMG-CoA reductase (HMGR) is tightly regulated, in part through post-transcriptional mechanisms that are mediated… Expand
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Highly Cited
1998
Highly Cited
1998
The zaragozic acids are potent inhibitors of squalene synthase. In vivo studies in mice confirmed our earlier observations that… Expand
1995
1995
Abstract: The effect of squalestatin 1 (SQ) on squalene synthase and other enzymes utilizing farnesyl pyrophosphate (F‐P‐P) as… Expand
Highly Cited
1995
Highly Cited
1995
Evidence has been obtained indicating that free farnesol (F-OH) can be utilized for isoprenoid biosynthesis in mammalian cells… Expand
1994
1994
The effects of squalestatin 1 on rat brain and liver homogenates and on Chinese hamster ovary tissue culture cells have been… Expand
Highly Cited
1993
Highly Cited
1993
synthetase (EC 2.5.1.21) is a microsomal enzyme which catalyzes the two sequential reactions: head-to-head condensation of… Expand
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1993
1993
Abstract The asymmetric syntheses of the C-1 sidechains of zaragozic acid A and C are described. Aldol reaction defines the… Expand