squalestatin 1

Known as: zaragozic acid A 
 

Topic mentions per year

Topic mentions per year

1992-2016
02419922016

Papers overview

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2010
2010
Farnesyl pyrophosphate (FPP), a key intermediate in the mevalonate pathway and protein farnesylation, can act as an agonist for… (More)
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2006
2006
OBJECTIVE In cells from patients with the autoinflammatory disorder mevalonate kinase (MK) deficiency, which includes the… (More)
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2002
2002
Because our previous studies indicated that squalestatin 1 treatment induces CYP2B expression in primary cultures of rat… (More)
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2001
2001
The surprising discovery that nitrogen-containing bisphosphonates (N-BPs) act via inhibition of the mevalonate-to-cholesterol… (More)
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1997
1997
Farnesyl diphosphate, the substrate for squalene synthase, accumulates in the presence of zaragozic acid A, a squalene synthase… (More)
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1996
1996
Inhibitors of cholesterol biosynthesis are believed to lower serum cholesterol levels by enhancing the removal of serum low… (More)
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1996
1996
A recent report, in which cultured tumor cells were used, identified farnesol as the nonsterol mevalonate-derived metabolite… (More)
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1994
1994
Squalene synthase catalyzes the committed step in the biosynthesis of sterols. Treating rats with zaragozic acid A, a potent… (More)
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Highly Cited
1993
Highly Cited
1993
Three closely related fungal metabolites, zaragozic acids A, B, and C, that are potent inhibitors of squalene synthase have been… (More)
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1992
1992
Squalestatin 1 is a member of a novel family of fermentation products isolated from a previously unknown Phoma species… (More)
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