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squalestatin 1

Known as: zaragozic acid A 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Farnesyl pyrophosphate (FPP), a key intermediate in the mevalonate pathway and protein farnesylation, can act as an agonist for… 
2008
Highly Cited
2002
Highly Cited
2002
Because our previous studies indicated that squalestatin 1 treatment induces CYP2B expression in primary cultures of rat… 
1999
1999
The activity of HMG-CoA reductase (HMGR) is tightly regulated, in part through post-transcriptional mechanisms that are mediated… 
Highly Cited
1998
Highly Cited
1998
The zaragozic acids are potent inhibitors of squalene synthase. In vivo studies in mice confirmed our earlier observations that… 
1995
1995
Abstract: The effect of squalestatin 1 (SQ) on squalene synthase and other enzymes utilizing farnesyl pyrophosphate (F‐P‐P) as… 
Highly Cited
1995
Highly Cited
1995
Evidence has been obtained indicating that free farnesol (F-OH) can be utilized for isoprenoid biosynthesis in mammalian cells… 
Highly Cited
1994
Highly Cited
1994
The recently discovered fungal metabolites known both as the squalestatins' and zaragozic acids2 have become attractive targets… 
Highly Cited
1993
Highly Cited
1993
synthetase (EC 2.5.1.21) is a microsomal enzyme which catalyzes the two sequential reactions: head-to-head condensation of…