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Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate.
The mechanism that make catechins cytotoxic in certain tumor cells is due to their ability to produce H(2)O( 2) and that the resulting increase in H-O-2 levels triggers Fe(II)-dependent formation of highly toxic hydroxyl radical, which in turn induces apoptotic cell death.
Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin
Investigation of the effect of a naturally occurring antiprotozoan antibiotic, ikarugamycin (IKA), on CD4 cell surface expression in human monocytic cells stably expressing HIV type 1 SF2 Nef suggests that IKA may be an efficient and useful inhibitor of CCP-dependent endocytosis.
Effects of Mulberry Leaf Extract Rich in 1-Deoxynojirimycin on Blood Lipid Profiles in Humans
The findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract.
Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774.
Results demonstrate that concanamycin-B inhibition of oxidized-LDL-induced accumulation of lipid droplets and cholesteryl esters in macrophages J774 is associated with reduced ATP-dependent acidification of these organelles.
Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber.
The present communication describes the isolation, structure and some of the biological properties of two new compounds designated monacolins J and L, both of which have shown the potential in treating hypocholesterolemic disorders.
Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification.
Four new analogues of concanamycin family were isolated from the mycelium of Streptomyces sp.
Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid).
A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured
SMTP-7, a Novel Small-Molecule Thrombolytic for Ischemic Stroke: A Study in Rodents and Primates
In normal monkeys, SMTP-7 did not affect general physiologic or hemostatic variables, including coagulation and platelet parameters, and is thus a promising candidate for the development of alternative therapy for ischemic stroke.
Inhibition of acyl-CoA: cholesterol acyltransferase by isohalobacillin, a complex of novel cyclic acylpeptides produced by Bacillus sp. A1238.
In a cell-free assay, isohalobacillin inhibited acyl-CoA: cholesterol acyltransferase by 50% at a concentration of 50 microM and inhibited oxidized low density lipoprotein-induced synthesis of cholesteryl ester from [14C]oleate without affecting surface binding, internalization and degradation of the lipop protein in the cells.
Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo.
It is shown that histone promotes pro-PHBP autoactivation in vivo and histone-mediated pro- PHBP activation in plasma leads to the formations of bradykinin and PHBP-α(2)-antiplasmin complex as well as histone degradation.