Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate.
- H. Nakagawa, K. Hasumi, J. Woo, K. Nagai, M. Wachi
- BiologyCarcinogenesis
- 1 September 2004
The mechanism that make catechins cytotoxic in certain tumor cells is due to their ability to produce H(2)O( 2) and that the resulting increase in H-O-2 levels triggers Fe(II)-dependent formation of highly toxic hydroxyl radical, which in turn induces apoptotic cell death.
Effects of Mulberry Leaf Extract Rich in 1-Deoxynojirimycin on Blood Lipid Profiles in Humans
- Y. Kojima, Toshiyuki Kimura, T. Miyazawa
- Biology, MedicineJournal of clinical biochemistry and nutrition
- 6 August 2010
The findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract.
Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin
- T. Luo, B. Fredericksen, K. Hasumi, A. Endo, J. Garcia
- BiologyJournal of Virology
- 1 March 2001
Investigation of the effect of a naturally occurring antiprotozoan antibiotic, ikarugamycin (IKA), on CD4 cell surface expression in human monocytic cells stably expressing HIV type 1 SF2 Nef suggests that IKA may be an efficient and useful inhibitor of CCP-dependent endocytosis.
Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber.
- A. Endo, K. Hasumi, S. Negishi
- ChemistryJournal of antibiotics (Tokyo. )
- 1 March 1985
The present communication describes the isolation, structure and some of the biological properties of two new compounds designated monacolins J and L, both of which have shown the potential in treating hypocholesterolemic disorders.
Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification.
- J. Woo, C. Shinohara, K. Sakai, K. Hasumi, A. Endo
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 July 1992
Four new analogues of concanamycin family were isolated from the mycelium of Streptomyces sp.
Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo.
- S. Yamamichi, Yukari Fujiwara, T. Kikuchi, M. Nishitani, Y. Matsushita, K. Hasumi
- Biology, ChemistryBiochemical and Biophysical Research…
- 10 June 2011
Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774.
- J. Woo, C. Shinohara, K. Sakai, K. Hasumi, A. Endo
- Biology, ChemistryEuropean Journal of Biochemistry
- 1 July 1992
Results demonstrate that concanamycin-B inhibition of oxidized-LDL-induced accumulation of lipid droplets and cholesteryl esters in macrophages J774 is associated with reduced ATP-dependent acidification of these organelles.
SMTP-7, a Novel Small-Molecule Thrombolytic for Ischemic Stroke: A Study in Rodents and Primates
- H. Sawada, N. Nishimura, K. Hasumi
- Biology, MedicineJournal of Cerebral Blood Flow and Metabolism
- 1 February 2014
In normal monkeys, SMTP-7 did not affect general physiologic or hemostatic variables, including coagulation and platelet parameters, and is thus a promising candidate for the development of alternative therapy for ischemic stroke.
Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis.
- A. Endo, K. Hasumi, T. Nakamura, M. Kunishima, M. Masuda
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 March 1985
The structures of dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are determined by a combination of physical techniques.
Activation of fibrinolysis by SMTP-7 and -8, novel staplabin analogs with a pseudosymmetric structure.
Two novel staplabin analogs, SMTP-7 and -8, have been isolated from cultures of Stachybotrys microspora IFO 30018 and caused 2- to 12-fold increase in urokinase-catalyzed plasminogen activation, fibrin binding of plas minogen, and uro Kinase- and plasMinogen-mediated fibrinolysis.
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