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Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets.
- R. Cox
- BiologyOrganic & biomolecular chemistry
- 20 June 2007
The current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases is outlined.
Design and utility of oligonucleotide gene probes for fungal polyketide synthases.
An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition
- I. Eleftherianos, S. Boundy, S. Reynolds
- BiologyProceedings of the National Academy of Sciences
- 13 February 2007
Photorhabdus produces a small-molecule antibiotic that also acts as an inhibitor of phenoloxidase (PO) in the insect host Manduca sexta, which has a dual function both as a PO inhibitor to counter host immune reactions and also as an antibiotic to exclude microbial competitors from the insect cadaver.
Minimum Information about a Biosynthetic Gene cluster.
This work proposes the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard, to facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters.
The molecular steps of citrinin biosynthesis in fungi† †Electronic supplementary information (ESI) available: All experimental, chromatographic, bioinformatic and spectroscopic details. See DOI:…
Heterologous expression of the citrinin polyketide synthase, CitS, plus the tailoring enzymes CitA–CitE from Monascus ruber has fully elucidated the biosynthetic pathway to citrinin for the first…
A chain initiation factor common to both modular and aromatic polyketide synthases
It is shown that a component of aromatic PKS, previously named ‘chain-length factor’, is a factor required for polyketide chain initiation and that this factor has decarboxylase activity towards malonyl-ACP (acyl carrier protein).
Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum
- Zhongshu Song, R. Cox, C. Lazarus, T. J. Simpson
- Biology, ChemistryChembiochem : a European journal of chemical…
- 6 September 2004
Targeted gene disruption produced a fusarin‐deficient strain of F. venenatum, thereby proving that this synthase is responsible for the first steps offusarin biosynthesis.
Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana.
- L. Halo, Mary N. Heneghan, T. J. Simpson
- BiologyJournal of the American Chemical Society
- 9 December 2008
It is shown that ORF1 encodes a cytochrome P450 oxidase, which catalyzes an unprecedented oxidative ring expansion of pretenellin-A to form the 2-pyridone core of tenellin and related metabolites, and that this enzyme does not catalyze the formation of a hydroxylated precursor.
Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis
A new biosynthetic pathway to the sorbicillinoid natural products is proposed based on the observation of oxidative dearomatisation of dihydrosorbicillin 10b.