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spicamycin

National Institutes of Health

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septacidin

Papers overview

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2004
2004
Antineuropathic effects of the antibiotic derivative spicamycin KRN5500.
Excellence in neuropathic pain management continues to challenge the ability of health care providers. Current medications are… 
2003
2003
A Single Intravenous Injection of KRN5500 (Antibiotic Spicamycin) Produces Long-Term Decreases in Multiple Sensory Hypersensitivities in Neuropathic Pain
Neuropathic pain is a significant clinical problem. Currently, there are no drugs that produce complete amelioration of this type… 
2000
2000
KRN5500 induces apoptosis (PCD) of myeloid leukemia cell lines and patient blasts.
1997
1997
Antiproliferative activity in vitro and in vivo of the spicamycin analogue KRN5500 with altered glycoprotein expression in vitro.
The spicamycin analogue KRN5500 (NSC 650426; SPA) is derived from Streptomyces alanosinicus. The unique structure contains a… 
1995
1995
Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity… 
1995
1995
In vitro cytotoxicity of a novel antitumor antibiotic, spicamycin derivative, in human lung cancer cell lines.
Spicamycin (SPM), produced by Streptomyces alanosinicus, induces potent differentiation in a human leukemia cell line, HL60. One… 
1995
1995
Absolute configuration of spicamycin, an antitumor antibiotic produced by Streptomyces alanosinicus.
a Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., 3, Miyahara-cho, Takasaki-shi, Gunma 370-12, Japan bThe Institute… 
1994
1994
Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells.
KRN5500, (6-[4-Deoxy-4-(2E,4E)-tetradecadienoylglycyl]amino-L-glycero - beta-L-mannoheptopyranosyl]amino-9H-purine), was semi… 
1994
1994
Antitumor activity of SPM VIII, a derivative of the nucleoside antibiotic spicamycin, against human tumor xenografts.
The antitumor activity of spicamycin analogue SPM VIII against human stomach, breast, lung, colon and esophageal cancers was… 
1983
1983
Studies on the differentiation inducers of myeloid leukemic cells. III. Spicamycin, a new inducer of differentiation of HL-60 human promyelocytic leukemia cells.
cells,1,2) we have recently isolated an active substance from the culture broth of a streptomycete. This antibiotic "spicamycin… 
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