Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.

  title={Structure-antitumor activity relationship of semi-synthetic Spicamycin derivatives.},
  author={Teruyuki Sakai and Hiroyasu Kawai and M Kamishohara and Akihiro Odagawa and Akinori Suzuki and Takeshi Uchida and Tomihisa Kawasaki and Takashi Tsuruo and Noboru Ōtake},
  journal={The Journal of antibiotics},
  volume={48 12},
New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII. 

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