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sorafenib tosylate

Known as: 4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate 
The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical… 
National Institutes of Health

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Related topics

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17-N-allylamino-17-demethoxygeldanamycin/sorafenibAngiogenesis InhibitionBRAF protein, humanFLT3 protein, human

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Papers overview

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Highly Cited
2014
Highly Cited
2014
A reagent-controlled SN2-glycosylation for the direct synthesis of β-linked 2-deoxy-sugars.
The efficient and stereoselective construction of glycosidic linkages remains one of the most formidable challenges in organic… 
2014
2014
A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours.
2014
2014
Site-specific chemical labeling of mitochondrial respiratory complex I through ligand-directed tosylate chemistry.
The site-specific chemical modification of NADH-quinone oxidoreductase (complex I) by various functional probes such as… 
2013
2013
Development of a new thiol site-specific prosthetic group and its conjugation with [Cys(40)]-exendin-4 for in vivo targeting of insulinomas.
A new tracer, N-5-[(18)F]fluoropentylmaleimide ([(18)F]FPenM), for site-specific labeling of free thiol group in proteins and… 
Review
2010
Review
2010
Bevacizumab, sorafenib tosylate, sunitinib and temsirolimus for renal cell carcinoma: a systematic review and economic evaluation.
OBJECTIVES To assess the clinical effectiveness and cost-effectiveness of bevacizumab, combined with interferon (IFN), sorafenib… 
Review
2009
Review
2009
Lessons learned from independent central review.
Review
2006
Review
2006
Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
Improvements in our understanding of the molecular basis of cancer have led to the clinical development of protein kinase… 
Highly Cited
2006
Highly Cited
2006
Cationic nucleoside lipids for gene delivery.
A novel uridine-based nucleo-lipid, DOTAU (N-[5'-(2',3'-dioleoyl)uridine]-N',N',N'-trimethylammonium tosylate) was prepared by… 
1989
1989
Sultamicillin
SummarySynopsisSultamicillin is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic… 
1974
1974
High-energy phosphate contents of subepicardium and subendocardium in the rat treated with isoproterenol and some other drugs.
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