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Tranexamic acid: a review of its use in surgery and other indications.
The drug reduces postoperative blood losses and transfusion requirements in a number of types of surgery, with potential cost and tolerability advantages over aprotinin, and appears to reduce rates of mortality and urgent surgery in patients with upper gastrointestinal haemorrhage. Expand
Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation.
Tacrolimus provides the clinician with an effective option for patients requiring immunosuppression and, with a different tolerability and efficacy profile to cyclosporin, it will better allow the tailoring of therapy to meet the needs of individual patients. Expand
Fluoxetine: a review of its therapeutic potential in the treatment of depression associated with physical illness.
Fluoxetine has shown superior efficacy compared with placebo in the treatment of depression in patients with HIV/AIDS, diabetes mellitus or stroke; however, it has not significantly improved depressive symptoms versus placebo in patientsWith cancer, and is safer in overdose than TCAs and monoamine oxidase inhibitors. Expand
Escitalopram : a review of its use in the management of major depressive and anxiety disorders.
Escitalopram is a highly selective inhibitor for the serotonin transporter, ameliorates depressive symptoms in patients with MDD at half the RS-citaloprams dosage, has a rapid onset of symptom improvement and has a predictable tolerability profile of generally mild adverse events. Expand
Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy.
Gabapentin provides notable benefit, reducing seizure frequency by > or = 50% in 18 to 28% of patients with refractory partial seizures, as shown in 3 double-blind, placebo-controlled trials. Expand
Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation.
The introduction of cyclosporin microemulsion has consolidated the place of the drug as a mainstay of therapy in all types of solid organ transplantation and savings in direct healthcare costs in kidney or liver transplantation are shown, although studies incorporating indirect costs or expressing costs in terms of therapeutic outcomes are currently unavailable. Expand
Valsartan. A review of its pharmacology and therapeutic use in essential hypertension.
Valsartan is an effective treatment for mild to moderate essential hypertension and may be particularly useful in patients who experience persistent cough during ACE inhibitor therapy. Expand
Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders.
Should future results support preliminary evidence of comparable efficacy to metoclopramide, domperidone and ranitidine (in oesophagitis), cisapride with its favourable tolerability profile should claim a prominent position in the therapy of patients with a variety of gastrointestinal motility disorders. Expand
Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.
Cyclosporin is a lipophilic cyclic polypeptide which produces calcium-dependent, specific, reversible inhibition of transcription of interleukin-2 and several other cytokines, most notably in TExpand
Telmisartan: a review of its use in hypertension.
Telmisartan was well tolerated in patients with mild to moderate hypertension and was significantly less likely to cause persistent, dry cough than lisinopril and was as effective as other major classes of antihypertensive agents at lowering blood pressure. Expand