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X-ray-computed tomography contrast agents.
X-ray computed tomography (CT) is a well-established tissue imaging technique employed in a variety of research and clinical settings.1 Specifically, CT is a non-invasive clinical diagnostic tool… Expand
Therapeutic and diagnostic applications of dendrimers for cancer treatment.
Dendrimers are prepared with a level of control not attainable with most linear polymers, leading to nearly monodisperse, globular macromolecules with a large number of peripheral groups. As a… Expand
Local drug delivery strategies for cancer treatment: gels, nanoparticles, polymeric films, rods, and wafers.
- Jesse B. Wolinsky, Y. Colson, M. Grinstaff
- Journal of controlled release : official journal…
- 10 April 2012
Polymer-based drug delivery depots have been investigated over the last several decades as a means to improve upon the lack of tumor targeting and severe systemic morbidities associated with… Expand
Photocrosslinkable polysaccharides for in situ hydrogel formation.
- K. A. Smeds, A. Pfister-Serres, +4 authors M. Grinstaff
- Materials Science, Medicine
- Journal of biomedical materials research
In situ photopolymerization is an exciting new technique for tissue engineering. Two photocrosslinkable polysaccharides composed of alginate and hyaluronan are described that upon photolysis form… Expand
Photocrosslinkable Hyaluronan as a Scaffold for Articular Cartilage Repair
- D. L. Nettles, T. Vail, Meredith T. Morgan, M. Grinstaff, L. Setton
- Chemistry, Medicine
- Annals of Biomedical Engineering
- 1 March 2004
Hyaluronan-based scaffolds are of interest for tissue-engineered cartilage repair due to an important role for hyaluronan in cartilage development and function. In this study, an in situ… Expand
Biomedical applications of dendrimers: a tutorial.
This tutorial review is written for first-year graduate students or senior undergraduates and "asks" andanswers" many of the questions that arise in our first discussions of dendrimers. Expand
The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial.
The closure and repair of wounds after traumatic or surgical injury is of significant clinical and research importance. While sutures remain the common wound closure technique, they have many… Expand
Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
- Meredith T. Morgan, Y. Nakanishi, +7 authors M. Grinstaff
- Chemistry, Medicine
- Cancer research
- 15 December 2006
A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and… Expand
Protein microencapsulation of nonaqueous liquids
In summary, ultrasound can produce proteinaceous microcapsules at high concentrations with narrow size distributions. The process involves both emulsification and a chemical cross-linking of protein… Expand
Mimicking the tumor microenvironment to regulate macrophage phenotype and assessing chemotherapeutic efficacy in embedded cancer cell/macrophage spheroid models.
- Kristie M. Tevis, Ryan J Cecchi, Y. Colson, M. Grinstaff
- Biology, Medicine
- Acta biomaterialia
- 1 March 2017
Tumor associated macrophages (TAMs) are critical stromal components intimately involved with the progression, invasion, and metastasis of cancer cells. To address the need for an in vitro system that… Expand