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shikonin

Known as: 5,8-dihydroxy-2-((1R)-1-hydroxy-4-methyl-3-penten-1-yl)-1,4-naphthalenedione, 1,4-naphthalenedione, 5,8-dihydroxy-2-((1r)-1-hydroxy-4-methyl-3-pentenyl)-, 1,4-naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (+)- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Anti-Inflammatory Agents, Non-SteroidalNaphthoquinones

Narrower (1)

shikonin, (+)-isomer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1.
Remodeling tumor immune microenvironment (TIME) is an important strategy to lift the immunosuppression and achieve immune… 
Review
2017
Review
2017
Antifungal effects of phytocompounds on Candida species alone and in combination with fluconazole.
Review
2016
Review
2016
Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants
The 1,4-naphthoquinones (1,4-NQs) are a diverse group of natural products found in every kingdom of life. Plants, including many… 
Review
2013
Review
2013
Pharmacological Properties of Shikonin – A Review of Literature since 2002
Abstract The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese herbal medicine made from the… 
Review
2012
Review
2012
Shikonin and its derivatives: a patent review
Introduction: Shikonin and its derivatives are the main components of red pigment extracts from Lithospermum erythrorhizon, whose… 
Highly Cited
2008
Highly Cited
2008
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells
This study examined the signaling events induced by shikonin that lead to the induction of apoptosis in Bcr/Abl-positive chronic… 
Review
2004
Review
2004
Separation methods of quinonoid constituents of plants used in Oriental traditional medicines.
Highly Cited
2002
Highly Cited
2002
Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.
Two cDNAs encoding geranyl diphosphate:4-hy- droxybenzoate 3-geranyltransferase were isolated from Lithospermum erythrorhizon by… 
Highly Cited
1986
Highly Cited
1986
A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin.
A pharmacological comparison between the enantiomers, shikonin (R) and alkannin (S), was made with regard to their inhibitory… 
Highly Cited
1977
Highly Cited
1977
Antitumor activity of shikonin and its derivatives.
Shikonin, a naphthoquinone contained in the root of Lithospermum officinalis var. erythrorhizon MAX. and Macrotomia euchroma… 
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