shikonin

Known as: 5,8-dihydroxy-2-((1R)-1-hydroxy-4-methyl-3-penten-1-yl)-1,4-naphthalenedione, 1,4-naphthalenedione, 5,8-dihydroxy-2-((1r)-1-hydroxy-4-methyl-3-pentenyl)-, 1,4-naphthoquinone, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (+)- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
020406019772017

Papers overview

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2013
2013
BACKGROUND AND PURPOSE Shikonin was reported to induce necroptosis in leukemia cells, but apoptosis in glioma cell lines. Thus… (More)
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Highly Cited
2011
Highly Cited
2011
We recently reported that shikonin and its analogs were a class of necroptotic inducers that could bypass cancer drug resistance… (More)
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2010
2010
Shikonin, a major ingredient in the Chinese traditional herb Lithospermum erythrorhixon, exhibits multiple biological functions… (More)
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2010
2010
The aim of our study was to investigate the neuroprotective properties of shikonin, a naphthoquinone pigment isolated from the… (More)
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Highly Cited
2009
Highly Cited
2009
Dysregulation of the ubiquitin-proteasome pathway plays an essential role in tumor growth and development. Shikonin, a natural… (More)
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Highly Cited
2009
Highly Cited
2009
Degterev et al. previously demonstrated that death receptor mediated apoptosis could be diverted to necroptosis when apoptosis… (More)
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Highly Cited
2007
Highly Cited
2007
Defect in apoptotic signaling and up-regulation of drug transporters in cancer cells significantly limits the effectiveness of… (More)
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2004
2004
Natural products regulate cell growth in response to oncogene activation that induces cell cycle arrest and apoptosis in tumor… (More)
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2003
2003
Shikonin is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine… (More)
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Highly Cited
1981
Highly Cited
1981
Shikonin derivatives were produced from cell suspension cultures of Lithospermum erythrorhizon for the first time. The results of… (More)
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