• Publications
  • Influence
An Update Review of Saffron and its Active Constituents
This paper reviews the literature on recent research on the chemical composition and pharmacological activities of saffron (Crocus sativus) and its active constituents, mainly as antitumoral,Expand
Structural considerations on the iridoids as anti-inflammatory agents.
The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation. Expand
Cocoa Polyphenols and Their Potential Benefits for Human Health
The phenolics from cocoa may protect against diseases in which oxidative stress is implicated as a causal or contributing factor, such as cancer, and have antiproliferative, antimutagenic, and chemoprotective effects in addition to their anticariogenic effects. Expand
Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF‐κB to the nucleus
The effect of shikonin on ear oedema induced by 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) is studied, and the mechanisms through which shik onin might exert its topical anti‐inflammatory action are determined. Expand
Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species.
The assayed phenolics exert varying degrees of protection against the chemical modifications induced by RNS depending not only on the hydroxyl pattern, but also on the presence of bicarbonate. Expand
Pharmacological properties of shikonin - a review of literature since 2002.
The aim of this review is to provide an update of the new data published on shikonin, whose wide spectrum of pharmacological effects as well as pharmacokinetic properties and toxicity make it a highly interesting target molecule. Expand
Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.
The inhibitory effect of PCE on acute UC induced by DSS in mice was attenuated by oral administration ofPCE obtained from cocoa, principally due to the inhibition of transcription factors STAT1 and STAT3 in intestinal cells, with NF-κB inhibition also being implicated. Expand
A chemotaxonomic survey of Sonchus subgenus Sonchus
Five species ofSonchus subgenus Sonchus were surveyed for their phenolic constituents and seven flavonoids were identified, including luteolin, lutenolin-7-glucoside, apigenin, apigin-3-gl Sucoside and quercetin- 3-galactoside. Expand
Lanostanoids from fungi: a group of potential anticancer compounds.
This review compiles the most relevant lanostanoids studied from 2000 to 2011, principally those isolated from Ganoderma lucidum and other related fungi, which have great potential as anticancer agents because of their cytotoxic or apoptotic effects. Expand
Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders.
The topical anti-inflammatory activity of extracts from Cassia angustifolia, Rheum palmatum, Coptis chinensis, Phellodendron amurense and Scutellaria baicalensis, plants used in traditional EastExpand