serotonin biosynthetic process

Known as: serotonin biosynthesis, serotonin anabolism, serotonin formation 
The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1958-2017
0204019582017

Papers overview

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Highly Cited
2005
Highly Cited
2005
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
Dysregulation of central serotonin neurotransmission has been widely suspected as an important contributor to major depression… (More)
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Highly Cited
2004
Highly Cited
2004
Tryptophan hydroxylase-2 controls brain serotonin synthesis.
Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is… (More)
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Highly Cited
2001
Highly Cited
2001
Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice.
Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor… (More)
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Highly Cited
2000
Highly Cited
2000
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
The functions of serotonin have been assigned through serotonin-receptor-specific drugs and mutants; however, because a… (More)
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Highly Cited
2000
Highly Cited
2000
Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons.
The long-term effects of hippocampal serotonergic denervation and reinnervation by foetal raphe tissue were examined in the… (More)
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Highly Cited
1999
Highly Cited
1999
Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children.
Serotonin content, serotonin uptake sites, and serotonin receptor binding measured in animal studies are all higher in the… (More)
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Highly Cited
1997
Highly Cited
1997
The Drosophila islet Gene Governs Axon Pathfinding and Neurotransmitter Identity
We have isolated the Drosophila homolog of the vertebrate islet-1 and islet-2 genes, two members of the LIM homeodomain family… (More)
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Highly Cited
1997
Highly Cited
1997
Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys.
Based on reports of increased platelet serotonin in 30 to 50% of autistic subjects, abnormal serotonergic neurotransmission may… (More)
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Highly Cited
1995
Highly Cited
1995
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be… (More)
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Highly Cited
1993
Highly Cited
1993
Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans.
Defining a behavior that requires the function of specific neurons in the free-living nematode Caenorhabditis elegans can allow… (More)
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