• Publications
  • Influence
Brain serotonin content: physiological regulation by plasma neutral amino acids.
TLDR
The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain. Expand
Branched-chain amino acids and brain function.
  • J. Fernstrom
  • Biology, Medicine
  • The Journal of nutrition
  • 1 June 2005
TLDR
It should be a straightforward exercise to design studies to assess dose-response relations for biochemical and functional effects of the BCAAs and, in this context, to explore for adverse effect thresholds. Expand
Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass.
TLDR
Within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass, and additional studies are needed to examine these findings over the longer term. Expand
Consensus meeting: monosodium glutamate – an update
TLDR
The general use of glutamate salts (monosodium-L-glutamate and others) as food additive can be regarded as harmless for the whole population and further research work should be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. Expand
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
TLDR
Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan and plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrationis that occur nocturnally in untreated aninmals as result of their normal 24-hour rhythms. Expand
Role of precursor availability in control of monoamine biosynthesis in brain.
  • J. Fernstrom
  • Chemistry, Medicine
  • Physiological reviews
  • 1 April 1983
NEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION 1
TLDR
The diet‐induced changes in the brain level of each of the amino acids also correlate surprisingly well with the calculated rate of brain influx for each amino acid. Expand
Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet
In the rat, the injection of insulin or the consumption of carbohydrate causes sequential increases in the concentrations of tryptophan in the plasma and the brain and of serotonin in the brain.Expand
Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain.
Aromatic amino acids in the brain function as precursors for the monoamine neurotransmitters serotonin (substrate tryptophan) and the catecholamines [dopamine, norepinephrine, epinephrine; substrateExpand
Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet.
  • J. Fernstrom
  • Chemistry, Medicine
  • The Journal of nutritional biochemistry
  • 1 October 1990
TLDR
Analyse de la relation entre la disponibilite en tyrosine et la synthese de dopamine, en tryptophane et the syntax de serotonine, et de l'effet de the phenylalanine comme substrat ou inhibiteur de the tyrosin hydroxylase. Expand
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