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Efficacy of a therapeutic cocaine vaccine in rodent models
Cocaine abuse is a major medical and public health concern in the United States, with approximately 2.1 million people dependent on cocaine1. Pharmacological approaches to the treatment of cocaineExpand
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Differential effects of self-administered cocaine in adolescent and adult rats on stimulus–reward learning
RationaleAdult cocaine addicts, abstinent at the time of testing, show a variety of neurocognitive impairments. Less clear is whether there are differences in the degree of impairment if cocaine useExpand
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Dissociable Effects of Lidocaine Inactivation of the Rostral and Caudal Basolateral Amygdala on the Maintenance and Reinstatement of Cocaine-Seeking Behavior in Rats
Cocaine addiction is a chronically relapsing brain disease, but its neural basis is not yet well understood. Clinical reports underscore the possible importance of associative processes forExpand
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Advancing the spontaneous hypertensive rat model of attention deficit/hyperactivity disorder.
To advance the spontaneous hypertensive rat (SHR) model of attention deficit/hyperactivity disorder (ADHD), experiments examined the SHR in tasks recognized to assess functioning of the prefrontalExpand
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Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus).
The influence of sex, phase of the estrous cycle, and age of drug onset on cocaine self-administration was examined. Adult male, adult female, and adolescent male rats (Rattus norvegicus) wereExpand
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D-cycloserine Deters Reacquisition of Cocaine Self-Administration by Augmenting Extinction Learning
Augmentation of cue exposure (extinction) therapy with cognitive-enhancing pharmacotherapy may offer an effective strategy to combat cocaine relapse. To investigate this possibility at theExpand
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Methylphenidate Treatment in Adolescent Rats with an Attention Deficit/Hyperactivity Disorder Phenotype: Cocaine Addiction Vulnerability and Dopamine Transporter Function
Appropriate animal models of attention deficit/hyperactivity disorder (ADHD) and drug reinforcement allow investigation of possible underlying biological bases of ADHD and its comorbidity withExpand
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Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model
Abstract Rationale: Previous pre-clinical studies with an anti-cocaine monoclonal antibody left open several issues critical to assessing the effectiveness of a vaccine for altering cocaineExpand
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Cognitive enhancers for facilitating drug cue extinction: Insights from animal models
Given the success of cue exposure (extinction) therapy combined with a cognitive enhancer for reducing anxiety, it is anticipated that this approach will prove more efficacious than exposure therapyExpand
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Effects of self-administered cocaine in adolescent and adult male rats on orbitofrontal cortex-related neurocognitive functioning
RationaleDeficits in amygdala-related stimulus-reward learning are produced following 18 drug-free days of cocaine self-administration or its passive delivery in rats exposed during adulthood. NoExpand
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