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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
The results demonstrate that the effects of ketamine are opposite to the synaptic deficits that result from exposure to stress and could contribute to the fast antidepressant actions of ketamines. Expand
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices
A new method for obtaining viable motoneurons in the facial nucleus of adult rat brain slices is described, in which NaCl was replaced initially by sucrose and the modified ACSF was used during slice preparation and a 1 hr recovery period. Expand
Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
The results indicate that the structural and functional deficits resulting from long-term stress exposure, which could contribute to the pathophysiology of depression, are rapidly reversed by NMDA receptor antagonists in a mammalian target of rapamycin dependent manner. Expand
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.
- B. S. Bunney, J. Walters, R. Roth, G. Aghajanian
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 June 1973
Neostriatal 3,4-dihydroxyphenylacetic acid was inceased by chlorpromazine, decreaed by amphetamine and unchanged by promethazine, thus paralleling the effects of these drugs on dopaminergic unit activity, compatible with the neuronal feedback hypothesis. Expand
Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.
- P. Delgado, D. Charney, L. Price, G. Aghajanian, H. Landis, G. Heninger
- Archives of general psychiatry
- 1 May 1990
The behavioral effects of rapid tryptophan depletion in patients in antidepressant-induced remission and the therapeutic effects of some antidepressant drugs may be dependent on serotonin availability are investigated. Expand
Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells
By intracellular and whole cell recording in rat brain slices, it was found that bath-applied serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory… Expand
Feedback regulation of central monoaminergic neurons: evidence from single cell recording studies.
- G. Aghajanian
- Essays in neurochemistry and neuropharmacology
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Treatment with new agents results in an improvement in mood ratings within hours of dosing patients who are resistant to typical antidepressants, and these new agents have also been shown to reverse the synaptic deficits caused by stress. Expand
Signaling pathways underlying the rapid antidepressant actions of ketamine
- R. Duman, N. Li, Rong‐jian Liu, V. Durić, G. Aghajanian
- Medicine, Psychology
- 31 January 2012
Together these studies indicate that ketamine rapidly reverses the atrophy of spines in the PFC and thereby causes a functional reconnection of neurons that underlies the rapid behavioral responses. Expand
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response. Expand