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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
The results demonstrate that the effects of ketamine are opposite to the synaptic deficits that result from exposure to stress and could contribute to the fast antidepressant actions of ketamines.
Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices
A new method for obtaining viable motoneurons in the facial nucleus of adult rat brain slices is described, in which NaCl was replaced initially by sucrose and the modified ACSF was used during slice preparation and a 1 hr recovery period.
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.
- B. S. Bunney, J. Walters, R. Roth, G. Aghajanian
- Biology, PsychologyThe Journal of pharmacology and experimental…
- 1 June 1973
Neostriatal 3,4-dihydroxyphenylacetic acid was inceased by chlorpromazine, decreaed by amphetamine and unchanged by promethazine, thus paralleling the effects of these drugs on dopaminergic unit activity, compatible with the neuronal feedback hypothesis.
Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.
- P. Delgado, D. Charney, L. Price, G. Aghajanian, H. Landis, G. Heninger
- Psychology, BiologyArchives of General Psychiatry
- 1 May 1990
The behavioral effects of rapid tryptophan depletion in patients in antidepressant-induced remission and the therapeutic effects of some antidepressant drugs may be dependent on serotonin availability are investigated.
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- R. Duman, G. Aghajanian, G. Sanacora, J. Krystal
- Psychology, BiologyNature Network Boston
- 1 March 2016
Treatment with new agents results in an improvement in mood ratings within hours of dosing patients who are resistant to typical antidepressants, and these new agents have also been shown to reverse the synaptic deficits caused by stress.
Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response.
Signaling pathways underlying the rapid antidepressant actions of ketamine