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mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Antidepressant Action of Ketamine In contrast to the weeks or months of treatment required for standard antidepressant medication, ketamine administration produces an antidepressant response within 4… Expand
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices
In general, it has been difficult to preserve electrophysiologically viable motoneurons in brain slices from adult mammals. The present study describes a new method for obtaining viable motoneurons… Expand
Molecular and cellular basis of addiction.
Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse. These adaptations combine to produce the complex behaviors that define an addicted… Expand
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.
- B. Bunney, J. Walters, R. Roth, G. Aghajanian
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 June 1973
The effects of amphetamine, various phenothiazines and haloperidol on dopaminergic neurons in the substantia nigra and ventral tegmental area of the rat midbrain were studied in anesthetized and… Expand
Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.
- P. Delgado, D. Charney, L. Price, G. Aghajanian, H. Landis, G. Heninger
- Psychology, Medicine
- Archives of general psychiatry
- 1 May 1990
Brain serotonin content is dependent on plasma levels of the essential amino acid tryptophan. We investigated the behavioral effects of rapid tryptophan depletion in patients in… Expand
Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
Extracellular and intracellular recordings were made from dorsal raphe (DR) neurons in frontal rat brain slices maintained in vitro. A population of neurons was found which displayed… Expand
Serotonin Induces Excitatory Postsynaptic Potentials in Apical Dendrites of Neocortical Pyramidal Cells
By intracellular and whole cell recording in rat brain slices, it was found that bath-applied serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory… Expand
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and… Expand
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Depression is a common, devastating illness. Current pharmacotherapies help many patients, but high rates of a partial response or no response, and the delayed onset of the effects of antidepressant… Expand
Signaling pathways underlying the rapid antidepressant actions of ketamine
- R. Duman, N. Li, R. Liu, Vanja Durić, G. Aghajanian
- Psychology, Medicine
- 31 January 2012
Currently available medications have significant limitations, most notably low response rate and time lag for treatment response. Recent clinical studies have demonstrated that ketamine, an NMDA… Expand