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sarpogrelate

Known as: 2-(dimethylamino)-1-((2-(3-methoxyphenyl)phenoxy)methyl)ethyl hydrogensuccinate hydrochloride, mono-(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl)ethyl)succinate hydrochloride 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Fibrinolytic AgentsPlatelet Aggregation InhibitorsSerotonin AntagonistsSuccinates

Narrower (1)

MCI 9042

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Sarpogrelate Hydrochloride, a Selective 5-HT2A Antagonist, Improves Vascular Function in Patients With Peripheral Arterial Disease
Peripheral arterial disease (PAD) is 1 of the major manifestations of atherosclerosis. PAD is associated with endothelial… 
2006
2006
Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages.
2006
2006
Inverse agonist activity of sarpogrelate, a selective 5-HT2A-receptor antagonist, at the constitutively active human 5-HT2A receptor.
Mutations producing constitutively active G-protein coupled receptors have been found in the pathophysiology of several diseases… 
2002
2002
Binding and Functional Affinity of Sarpogrelate, Its Metabolite M-1 and Ketanserin for Human Recombinant Alpha-1-Adrenoceptor Subtypes
Serotonin (5-HT2) antagonists show high affinity for the α1-adrenoceptor (α1-AR) in addition to the 5-HT2 receptor. In the… 
2002
2002
Pharmacological profiles of R-96544, the active form of a novel 5-HT2A receptor antagonist R-102444.
2002
2002
Sarpogrelate, a specific 5ht2‐receptor antagonist, improves the coronary microcirculation in coronary artery disease
Background: Serotonin (5‐hydroxytryptamine: 5‐HT) reduces the coronary blood flow (CBF) as a product of aggregating platelets… 
2001
2001
Serotonin potentiates angiotensin II--induced vascular smooth muscle cell proliferation.
2001
2001
Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time.
2000
2000
Influence of 5‐hydroxytryptamine and the effect of a new serotonin receptor antagonist (sarpogrelate) on detrusor smooth muscle of streptozotocin‐induced diabetes mellitus in the rat *
Background : We evaluated the changes in the response of detrusor muscle to 5‐hydroxytryptamine (5‐HT; serotonin) and its… 
2000
2000
Enhanced serotonin-mediated responses in the nucleus tractus solitarius of spontaneously hypertensive rats
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