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sarpogrelate

Known as: 2-(dimethylamino)-1-((2-(3-methoxyphenyl)phenoxy)methyl)ethyl hydrogensuccinate hydrochloride, mono-(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl)ethyl)succinate hydrochloride 
 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Fibrinolytic AgentsPlatelet Aggregation InhibitorsSerotonin AntagonistsSuccinates

Narrower (1)

MCI 9042

Papers overview

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Highly Cited
2008
Highly Cited
2008
Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS): A randomized, double-blind, aspirin-controlled trial.
BACKGROUND AND PURPOSE The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine receptors. The purpose… Expand
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2007
2007
Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease.
Peripheral arterial disease (PAD) is 1 of the major manifestations of atherosclerosis. PAD is associated with endothelial… Expand
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2007
2007
Effect of Sarpogrelate, a 5-HT2A Antagonist, on Platelet Aggregation in Patients with Ischemic Stroke: Clinical-Pharmacological Dose-Response Study
Background and Purpose: It is widely accepted that antiplatelet therapy is effective for secondary prevention of atherosclerotic… Expand
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Review
2004
Review
2004
Therapeutic potentials of sarpogrelate in cardiovascular disease.
In view of the pivotal role of serotonin (5-HT) in a wide variety of cardiovascular disorders, extensive effort has been made to… Expand
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2003
2003
Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism.
Although sarpogrelate HCl is widely used for the prevention of arterial thrombosis, its effect on atherosclerosis is unknown… Expand
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2003
2003
Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling.
The aim of the present study was to investigate the binding sites interactions and the selectivity of sarpogrelate to human 5-HT… Expand
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2003
2003
Sarpogrelate treatment reduces restenosis after coronary stenting.
BACKGROUND Sarpogrelate, a serotonin blocker, has been reported to inhibit the serotonin-induced proliferation of rat aortic… Expand
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2002
2002
Binding and Functional Affinity of Sarpogrelate, Its Metabolite M-1 and Ketanserin for Human Recombinant Alpha-1-Adrenoceptor Subtypes
Serotonin (5-HT2) antagonists show high affinity for the α1-adrenoceptor (α1-AR) in addition to the 5-HT2 receptor. In the… Expand
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2000
2000
Antinociception in rat by sarpogrelate, a selective 5-HT(2A) receptor antagonist, is peripheral.
The antinociceptive effect of sarpogrelate, a new selective 5-hydroxytriptamine (5-HT)(2A) receptor antagonist, in the formalin… Expand
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1999
1999
Inhibition of serotonin-induced vascular smooth muscle cell proliferation by sarpogrelate.
Antiproliferative behavior of sarpogrelate (Anplag, MCI-9042, (+/-)-1-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-3-(dimethylamino)-2… Expand
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