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Binding and Functional Affinity of Sarpogrelate, Its Metabolite M-1 and Ketanserin for Human Recombinant Alpha-1-Adrenoceptor Subtypes
TLDR
The present results indicate that sarpogrelate and M-1 have antagonistic activity to the three α1-AR subtypes, but their affinities are significantly lower than those of ketanserin.
Constitutively active mutant N111G of angiotensin II type 1 (AT(1)) receptor induces homologous internalization through mediation of AT(1)-receptor antagonist.
TLDR
The results indicate that internalization of CAM N111G of the AT(1) receptor is induced by the use of valsartan, which may be an important characteristic of inverse agonist activities of AT( 1) antagonists in N 111G.
Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents.
TLDR
It is suggested that beta-adrenoceptor antagonists can bind to beta- adrenoceptors and 5HT1B-receptors.
Characterization of rat myocardial sarcolemma.
Effect of hypoxia on mechanical function in the neonatal mammalian heart.
TLDR
The fact that the newborn was able to maintain normal mechanical function during hypoxia suggests that the infant is capable of maintaining normal myocardial ATP levels due to enhanced flux through the glycolytic pathway.
Effect of hypoxia on myocardial high-energy phosphates in the neonatal mammalian heart.
TLDR
The data indicate that the newborn rabbit is capable of maintaining glycolysis and normal levels of myocardial ATP during hypoxia, which ensures normal myocardIAL mechanical function for longer periods than in the adult.
MCI-9042: high affinity for serotonergic receptors as assessed by radioligand binding assay.
TLDR
The present study suggests that MCI-9042 is specific for 5HT2-receptor.
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