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Prostaglandin E2 Protects the Heart From Ischemia-Reperfusion Injury via Its Receptor Subtype EP4
TLDR
Both endogenous PGE2 and an exogenous EP4 agonist protect the heart from I/R injury via EP4, and the potent cardioprotective effects of 4819-CD suggest that the compound would be useful for treatment of acute myocardial infarction.
View on Wolters Kluwer
Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes.
TLDR
The present results show that many 5-HT-receptor antagonists and agonists have high affinity to alpha1-adrenoceptors, but suggest that there is deviation between their functional affinities and binding affinITIES for some drugs.
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No evidence for AT2R gene derangement in human urinary tract anomalies.
TLDR
Findings indicate that the AT2R gene may not play a major role in the development of renal hypoplasia and other CAKUT in humans, at least in the Japanese population.
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Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.
TLDR
The data suggest that there has been an acquisition of a paternal epigenotype in Wilms tumors as the result of a pathologic disruption in the normal imprinting of the IGF2 and H19 genes.
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Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.
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Protein phosphatases that regulate multifunctional Ca2+/calmodulin-dependent protein kinases: from biochemistry to pharmacology.
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Somatic overgrowth associated with overexpression of insulin–like growth factor II
TLDR
The accumulated data on normal and pathologic IGF2 expression are now sufficient to define an entity, “IGF2 overgrowth disorder,” of which BWS may be one extreme manifestation, and have broad implications for the characterization of idiopathic overgrowth.
View on Springer
Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells
TLDR
It is found that cancer cells (PSK-1) derived from a patient with Klinefelter syndrome (47XXY) showing loss of an inactive X chromosome subsequently gained active X chromosomes.
View on Nature
Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation
TLDR
It is postulate that LOI in Wilms tumours is associated with loss of maternal allele-specific methylation from a region located upstream of the imprinted IGF2 promoters, which may contain cis acting sequences that coordinately influence imprinting.
View on Nature
Inverse agonism and neutral antagonism at a constitutively active alpha‐1a adrenoceptor
TLDR
Results indicated that a neutral antagonist can reverse the action of an inverse agonist at the receptor site, which may be important for the clinical use of such antagonists.
View on Wiley
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