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saquinavir mesylate
Known as:
Monomethanesulfonate, Saquinavir
, Saquinavir Monomethanesulfonate
, Saquinavir Monomethanesulfonate [Chemical/Ingredient]
A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.
National Institutes of Health
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Related topics
Related topics
15 relations
Acquired Immunodeficiency Syndrome
Astemizole
Drug Allergy
Ergotamines
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Narrower (1)
Invirase
Broader (3)
Isoquinolines
Quinolines
Saquinavir
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting
H. Mahajan
,
M. Mahajan
,
P. Nerkar
,
A. Agrawal
Drug delivery
2014
Corpus ID: 21168916
Abstract The central nervous system (CNS) is an immunological privileged sanctuary site-providing reservoir for HIV-1 virus…
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2012
2012
Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement.
M. Branham
,
T. Moyo
,
T. Govender
European journal of pharmaceutics and…
2012
Corpus ID: 5603395
Saquinavir is an anti-retroviral drug with very low oral bioavailability (e.g. 0.7-4.0%) due to its affinity toward efflux…
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2008
2008
Pharmacokinetics of saquinavir after intravenous and oral dosing of saquinavir: hydroxybutenyl-beta-cyclodextrin formulations.
C. Buchanan
,
N. L. Buchanan
,
+5 authors
M. Wempe
Biomacromolecules
2008
Corpus ID: 5544164
The current research evaluated the ability of hydroxybutenyl-beta-cyclodextrin (HBenBCD) to enhance saquinavir in vitro…
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Highly Cited
2004
Highly Cited
2004
Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers
J. Alsenz
,
H. Steffen
,
R. Alex
Pharmaceutical Research
2004
Corpus ID: 9138723
AbstractPurpose. To investigate in vitro the mechanisms involved in the gastrointestinal absorption of the HIV protease inhibitor…
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Highly Cited
2004
Highly Cited
2004
Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.
Yaming Su
,
X. Zhang
,
P. Sinko
Molecular pharmaceutics
2004
Corpus ID: 37109861
Saquinavir mesylate (SQV) is the first-in-class and prototypical HIV protease inhibitor (PI) used in the treatment of HIV…
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Highly Cited
2002
Highly Cited
2002
Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2)
G. C. Williams
,
A. Liu
,
G. Knipp
,
P. Sinko
Antimicrobial Agents and Chemotherapy
2002
Corpus ID: 34500891
ABSTRACT To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1…
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Highly Cited
2000
Highly Cited
2000
Predictors of virological success and ensuing failure in HIV-positive patients starting highly active antiretroviral therapy in Europe: results from the EuroSIDA study.
R. Paredes
,
A. Mocroft
,
+7 authors
B. Clotet
Archives of internal medicine
2000
Corpus ID: 11405712
BACKGROUND Predictors of virological response to highly active antiretroviral therapy (HAART) have never been systematically…
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Highly Cited
1998
Highly Cited
1998
Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein.
A. Kim
,
J. M. Dintaman
,
D. Waddell
,
J. Silverman
The Journal of pharmacology and experimental…
1998
Corpus ID: 3066050
Saquinavir, a peptidomimetic HIV protease inhibitor, has been shown to be effective in reducing patient viral load and reducing…
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1993
1993
Possible Bromocriptine-Induced Myocardial Infarction
F. Larrazet
,
C. Spaulding
,
H. J. Lobreau
,
S. Weber
,
François Guérin
Annals of Internal Medicine
1993
Corpus ID: 29493937
Bromocriptine is commonly used for the suppression of lactation in the postpartum period. Bromocriptine mesylate (2-bromo…
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Highly Cited
1990
Highly Cited
1990
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
E. J. Jacobsen
,
John M. McCall
,
+7 authors
M. Krook
Journal of medicinal chemistry
1990
Corpus ID: 46187810
A novel class of 21-aminosteroids has been developed. Compounds within this series are potent inhibitors of iron-dependent lipid…
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