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saquinavir mesylate

Known as: Monomethanesulfonate, Saquinavir, Saquinavir Monomethanesulfonate, Saquinavir Monomethanesulfonate [Chemical/Ingredient] 
A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.
National Institutes of Health

Related topics

Related topics

15 relations
Acquired Immunodeficiency SyndromeAstemizoleDrug AllergyErgotamines
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Narrower (1)

Invirase

Broader (3)

IsoquinolinesQuinolinesSaquinavir

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting
Abstract The central nervous system (CNS) is an immunological privileged sanctuary site-providing reservoir for HIV-1 virus… Expand
2012
2012
Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement.
Saquinavir is an anti-retroviral drug with very low oral bioavailability (e.g. 0.7-4.0%) due to its affinity toward efflux… Expand
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2008
2008
Pharmacokinetics of saquinavir after intravenous and oral dosing of saquinavir: hydroxybutenyl-beta-cyclodextrin formulations.
The current research evaluated the ability of hydroxybutenyl-beta-cyclodextrin (HBenBCD) to enhance saquinavir in vitro… Expand
Highly Cited
2004
Highly Cited
2004
Active Apical Secretory Efflux of the HIV Protease Inhibitors Saquinavir and Ritonavir in Caco-2 Cell Monolayers
AbstractPurpose. To investigate in vitro the mechanisms involved in the gastrointestinal absorption of the HIV protease inhibitor… Expand
Highly Cited
2004
Highly Cited
2004
Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.
Saquinavir mesylate (SQV) is the first-in-class and prototypical HIV protease inhibitor (PI) used in the treatment of HIV… Expand
Highly Cited
2002
Highly Cited
2002
Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2)
ABSTRACT To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1… Expand
Highly Cited
2000
Highly Cited
2000
Predictors of virological success and ensuing failure in HIV-positive patients starting highly active antiretroviral therapy in Europe: results from the EuroSIDA study.
BACKGROUND Predictors of virological response to highly active antiretroviral therapy (HAART) have never been systematically… Expand
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Highly Cited
1998
Highly Cited
1998
Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein.
Saquinavir, a peptidomimetic HIV protease inhibitor, has been shown to be effective in reducing patient viral load and reducing… Expand
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1993
1993
Possible Bromocriptine-Induced Myocardial Infarction
Bromocriptine is commonly used for the suppression of lactation in the postpartum period. Bromocriptine mesylate (2-bromo… Expand
Highly Cited
1990
Highly Cited
1990
Novel 21-aminosteroids that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma.
A novel class of 21-aminosteroids has been developed. Compounds within this series are potent inhibitors of iron-dependent lipid… Expand
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