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Saquinavir

Known as: SQV, Saquinavir [Chemical/Ingredient], Saquinivir 
An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases… 
National Institutes of Health

Related topics

Related topics

34 relations
Acquired Immunodeficiency SyndromeAstemizoleCYP3A7 protein, humanDrug Allergy

Broader (6)

Antiviral AgentsCytochrome P-450 CYP3A InhibitorsHIV Protease InhibitorsIsoquinolines

Narrower (3)

Inviraseascorbyl-succinic-saquinavirsaquinavir-NO

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease
Review
2012
Review
2012
Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs
Introduction : More than 40% of new chemical entities discovered are poorly water soluble and suffer from low oral… 
Highly Cited
2009
Highly Cited
2009
Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine
The non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is directly conjugated by the UDP-glucuronosyltransferase (UGT… 
Highly Cited
2006
Highly Cited
2006
The HIV-AIDS pandemic at 25--the global response.
The AIDS crisis demanded a unique and truly global response. Instead, AIDS often engendered stigma, discrimination, and denial… 
Highly Cited
2006
Highly Cited
2006
Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: Protease inhibitor–mediated neurotoxicity
Human immunodeficiency virus–associated sensory neuropathy (HIV‐SN) is a common and disabling disorder, often associated with… 
Highly Cited
2005
Highly Cited
2005
Blockade of HERG channels by HIV protease inhibitors
Highly Cited
2000
Highly Cited
2000
Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography.
Highly Cited
1999
Highly Cited
1999
Virologic responses to a ritonavir--saquinavir-containing regimen in patients who had previously failed nelfinavir.
OBJECTIVES The effectiveness of a second protease inhibitor in patients who failed an initial protease inhibitor is unclear but… 
Highly Cited
1996
Highly Cited
1996
The Effect of High-Dose Saquinavir on Viral Load and CD4+ T-Cell Counts in HIV-Infected Patients
Human immunodeficiency virus (HIV) protease inhibitors are a new class of antiretroviral agents that target a different point in… 
Review
1996
Review
1996
Antiretroviral therapy in adults.
In 1993, HIV became the leading cause of death among persons 25 to 44 years old (Centers for Disease Control and Prevention [CDC… 
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