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Saquinavir

Known as: SQV, Saquinavir [Chemical/Ingredient], Saquinivir 
An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases… 
National Institutes of Health

Related topics

Related topics

34 relations
Acquired Immunodeficiency SyndromeAstemizoleCYP3A7 protein, humanDrug Allergy

Broader (6)

Antiviral AgentsCytochrome P-450 CYP3A InhibitorsHIV Protease InhibitorsIsoquinolines

Narrower (3)

Inviraseascorbyl-succinic-saquinavirsaquinavir-NO

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
On-line desorption of dried blood spot: A novel approach for the direct LC/MS analysis of micro-whole blood samples.
Highly Cited
2007
Highly Cited
2007
Association of Gag cleavage sites to protease mutations and to virological response in HIV-1 treated patients.
Highly Cited
2005
Highly Cited
2005
Determination of antiretroviral agents in human serum by capillary electrophoresis.
Highly Cited
2003
Highly Cited
2003
Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography.
Highly Cited
1999
Highly Cited
1999
Virologic responses to a ritonavir--saquinavir-containing regimen in patients who had previously failed nelfinavir.
OBJECTIVES The effectiveness of a second protease inhibitor in patients who failed an initial protease inhibitor is unclear but… 
Highly Cited
1999
Highly Cited
1999
Baseline HIV drug resistance profile predicts response to ritonavir-saquinavir protease inhibitor therapy in a community setting.
OBJECTIVE To determine whether baseline drug resistance assays could help to predict treatment failure with the protease… 
Highly Cited
1998
Highly Cited
1998
Improvement in cell-mediated immune function during potent anti-human immunodeficiency virus therapy with ritonavir plus saquinavir.
Inhibiting human immunodeficiency virus (HIV) replication with potent antiretroviral therapy may result in improved immune… 
Highly Cited
1998
Highly Cited
1998
Activity of a ritonavir plus saquinavir‐containing regimen in patients with virologic evidence of indinavir or ritonavir failure
Objective:To evaluate the virologic activity of a ritonavir plus saquinavir–containing regimen in patients who have failed an… 
Review
1998
Review
1998
Resistance and cross-resistance with saquinavir and other HIV protease inhibitors: theory and practice.
The addition of the HIV protease inhibitors to the growing list of antiretrovirals, and the increasing acceptance of polypharmacy… 
Highly Cited
1997
Highly Cited
1997
Toxicity, efficacy, plasma drug concentrations and protease mutations in patients with advanced HIV infection treated with ritonavir plus saquinavir
Objective:To assess the safety, efficacy and plasma drug levels of the combination of ritonavir plus saquinavir for the treatment… 
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