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Cytochrome P-450 CYP3A Inhibitors

Known as: P450 CYP3A Inhibitors, CYP3A Inhibitors, Inhibitors, CYP3A 
Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP3A.
National Institutes of Health

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AmiodaroneClarithromycinCytochrome P-450 CYP3A5 InhibitorsCytochrome P-450 CYP3A7 Inhibitors
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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2020
2020
UDP‐Glucuronosyltransferase (UGT)‐mediated attenuations of cytochrome P450 3A4 activity: UGT isoform‐dependent mechanism of suppression
Cytochrome P450 (CYP, P450) 3A4 is involved in the metabolism of 50% of drugs and its catalytic activity in vivo is not explained… 
2018
2018
Improved Predictions of Drug-Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A.
Time-dependent inactivation (TDI) of cytochrome P450s (CYPs) is a leading cause of clinical drug-drug interactions (DDIs… 
2017
2017
Clinical Drug–Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor Alectinib
The efficacy and safety of alectinib, a central nervous system–active and selective anaplastic lymphoma kinase (ALK) inhibitor… 
2014
2014
Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350).
2014
2014
Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: core region.
2012
2012
Evidence of CYP3A Allosterism In Vivo: Analysis of Interaction Between Fluconazole and Midazolam
The allosteric effect of fluconazole (effector) on the formation of 1′–hydroxymidazolam (1′–OH–MDZ) and 4–hydroxymidazolam (4–OH… 
Highly Cited
2005
Highly Cited
2005
Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9‐hydroxyrisperidone in schizophrenic patients
Highly Cited
2004
Highly Cited
2004
Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs.
The objectives of this study were to characterize and compare the reversible inhibition and time-dependent inactivation of… 
1999
1999
Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo.
1. The aim was to identify whether CYP3A metabolizes bromperidol (BP), an antipsychotic drug, to form 4-fluorobenzoyl-propionic… 
Highly Cited
1993
Highly Cited
1993
Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions.
Metabolism of amiodarone to its N-deethylated derivative was investigated on a bank of human hepatic microsomal fractions, two of… 
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