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Limited frequency of the CYP2C19*17 allele and its minor role in a Japanese population.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT A novel CYP2C19 gene variant, CYP2C19*17, is associated with increased metabolic activity. Ethnic differences in the frequency of the variant allele have beenExpand
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The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans
Objective The objective was to determine the effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. Methods Individuals wereExpand
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Different Effects of Three Transporting Inhibitors, Verapamil, Cimetidine, and Probenecid, on Fexofenadine Pharmacokinetics
Fexofenadine is a substrate of P‐glycoprotein and organic anion transporting polypeptides. The aim of this study was to compare the inhibitory effects of different transporting inhibitors onExpand
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A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy.
We immunochemically measured the contents of 9 different cytochrome P450 (CYP) isoenzymes expressed in the liver and compared them between two groups: one group of 6 infant and 4 perinatal patientsExpand
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The Effect of Aging on the Relationship between the Cytochrome P450 2C19 Genotype and Omeprazole Pharmacokinetics
Background and objectiveThe metabolic activity of cytochrome P450 (CYP) 2C19 is genetically determined, and the pharmacokinetics of omeprazole, a substrate for CYP2C19, are dependent on the CYP2C19Expand
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The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Recently, we have shown that the plasma concentration of R-fexofenadine is greater than that of the S-enantiomer. Although itraconazole co-administration isExpand
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Re: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.
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No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins.
Ethnic differences in the pharmacokinetics of nifedipine, a substrate of CYP3A, and in CYP3A7 expression have been reported. The aim of the present study was to measure the protein levels of CYP3A4,Expand
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Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism.
AIMS To examine the effect of ticlopidine administration on the activities CYP2C19 and CYP3 A in vivo using omeprazole as a model substrate. METHODS A single dose of 40 mg omeprazole wasExpand
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Analysis of the CYP2D6 gene in relation to dextromethorphan O‐demethylation capacity in a Japanese population
To analyze the CYP2D6 allele frequencies in a Japanese population and to evaluate the effects of CYP2D6 variants on in vivo CYP2D6 activity as measured by the dextromethorphan metabolic ratio (MR).
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