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- Publications
- Influence
EFFECT OF CYP3A5 POLYMORPHISM ON TACROLIMUS METABOLIC CLEARANCE IN VITRO
- Yang Dai, M. Hebert, +4 authors K. Thummel
- Biology, Medicine
- Drug Metabolism and Disposition
- 1 May 2006
Previous investigations of solid organ transplant patients treated with tacrolimus showed that individuals carrying a CYP3A5*1 allele have lower dose-adjusted trough blood concentrations compared… Expand
ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION
- N. Isoherranen, K. Kunze, Kyle E. Allen, W. L. Nelson, K. Thummel
- Chemistry, Medicine
- Drug Metabolism and Disposition
- 1 October 2004
Itraconazole (ITZ) is a potent inhibitor of CYP3A in vivo. However, unbound plasma concentrations of ITZ are much lower than its reported in vitro Ki, and no clinically significant interactions would… Expand
EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM
- W. Huang, Y. Lin, +5 authors K. Thummel
- Chemistry, Medicine
- Drug Metabolism and Disposition
- 1 December 2004
CYP3A4 and CYP3A5 exhibit significant overlap in substrate specificity but can differ in product regioselectivity and formation activity. To further explore this issue, we compared the kinetics of… Expand
Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 In Vivo
- I. Templeton, K. Thummel, +4 authors N. Isoherranen
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 January 2008
Itraconazole (ITZ) is metabolized in vitro to three inhibitory metabolites: hydroxy‐itraconazole (OH‐ITZ), keto‐itraconazole (keto‐ITZ), and N‐desalkyl‐itraconazole (ND‐ITZ). The goal of this study… Expand
Processive Pulses of Retinoic Acid Propel Asynchronous and Continuous Murine Sperm Production1
- C. Hogarth, S. Arnold, Travis M. Kent, D. Mitchell, N. Isoherranen, Michael Griswold
- Biology, Medicine
- Biology of reproduction
- 1 February 2015
ABSTRACT The asynchronous cyclic nature of spermatogenesis is essential for continual sperm production and is one of the hallmarks of mammalian male fertility. While various mRNA and protein… Expand
The role of CYP26 enzymes in retinoic acid clearance
- Jayne E Thatcher, N. Isoherranen
- Biology, Medicine
- Expert opinion on drug metabolism & toxicology
- 21 July 2009
Retinoic acid (RA) is a critical signaling molecule that regulates gene transcription and the cell cycle. Understanding of RA signaling has increased dramatically over the past decades, but the… Expand
Qualitative analysis of the role of metabolites in inhibitory drug-drug interactions: literature evaluation based on the metabolism and transport drug interaction database.
- N. Isoherranen, H. Hachad, C. K. Yeung, R. Levy
- Biology, Medicine
- Chemical research in toxicology
- 16 February 2009
Guidance from the Food and Drug Administration on drug interaction studies does not include a specific section on contributions of metabolites to observed inhibitory drug-drug interactions, and the… Expand
Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase.
- J. Lutz, V. Dixit, +5 authors N. Isoherranen
- Biology, Medicine
- Biochemical pharmacology
- 15 January 2009
Retinoic acid (RA) is a critical signaling molecule that performs multiple functions required to maintain cellular viability. It is also used in the treatment of some cancers. Enzymes in the CYP26… Expand
The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid.
- Jayne E Thatcher, Alex Zelter, N. Isoherranen
- Biology, Medicine
- Biochemical pharmacology
- 15 September 2010
All-trans retinoic acid (RA) is a critical signaling molecule and its concentration is tightly regulated. Several P450 enzymes including CYP26A1, CYP2C8, and CYP3A4 have been proposed to be… Expand
Are Circulating Metabolites Important in Drug–Drug Interactions?: Quantitative Analysis of Risk Prediction and Inhibitory Potency
- C. Yeung, Y. Fujioka, H. Hachad, R. Levy, N. Isoherranen
- Chemistry, Medicine
- Clinical pharmacology and therapeutics
- 1 January 2011
The potential of metabolites to contribute to drug–drug interactions (DDIs) is not well defined. The aim of this study was to determine the quantitative role of circulating metabolites in inhibitory… Expand