Cancer prevention by natural compounds.
- H. Tsuda, Yutaka Ohshima, M. Moore
- Biology, ChemistryDrug Metabolism and Pharmacokinetics
- 2004
Natural agents are advantageous for application to humans because of their combined mild mechanism and here they are reviewed based on in vivo studies with reference to their structures, sources and mechanisms of action.
Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice
- A. Takagi, A. Hirose, M. Futakuchi, H. Tsuda, J. Kanno
- Medicine, BiologyCancer Science
- 27 April 2012
Findings were in favor of the widely proposed mode of action of fiber carcinogenesis, that is, frustrated phagocytosis where the mesotheliomagenic microenvironment on the peritoneal surface is neither qualitatively altered by the density of the fibers per area nor by the formation of granulomas against agglomerates.
Tumours of the kidney.
- H. Tsuda, D. J. Kim, T. Kato, K. Hakoi, A. Hagiwara
- MedicineIARC scientific publications
- 1996
Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system.
It is concluded that the present experimental protocol which requires far fewer animals and shorter duration than a long-term carcinogenicity test has practical applications for the rapid and economical screening of environmental hepatocarcinogens and their inhibitory agents.
Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis.
- N. Ito, M. Hirose, S. Fukushima, H. Tsuda, T. Shirai, M. Tatematsu
- MedicineFood and Chemical Toxicology
- 1 October 1986
Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors
- M. Suzui, M. Futakuchi, H. Tsuda
- Medicine, BiologyCancer Science
- 23 June 2016
Investigation of the carcinogenicity of MWCNT‐N (NIKKISO) after administration to the rat lung found it induces malignant mesothelioma and lung tumors.
Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens.
- A. Naiki‐Ito, M. Asamoto, T. Shirai
- BiologyCancer Research
- 1 December 2007
DNA microarray analysis revealed that glutathione peroxidase 2 (Gpx2) was commonly up-regulated in the mammary carcinomas induced by the three different carcinogens, and its up-regulation was confirmed by quantitative reverse transcriptase-PCR and Western blotting analysis, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer.
Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants.
- N. Ito, S. Fukushima, H. Tsuda
- Medicine, BiologyCritical Reviews in Toxicology
- 1985
Results indicate that BHA should be classified in the category of "sufficient evidence of carcinogenicity" as judged by IARC criteria, and the 3-tert isomer of BHA seemed to be responsible for the carcinogensicity of crude BHA in the forestomach of rats.
Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo
- V. Krutovskikh, S. Troyanovsky, C. Piccoli, H. Tsuda, M. Asamoto, H. Yamasaki
- BiologyOncogene
- 27 January 2000
Results show that cell coupling is a strong, but not the sole, mechanism by which Cx suppresses growth of tumorigenic cells in vivo; a GJIC-independent activity of Cx proteins should be considered as another strong tumor-suppressive factor.
Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes
- Jiegou Xu, D. Alexander, H. Tsuda
- BiologyCancer Science
- 1 July 2014
Results suggest that MWCNT‐L has higher risk of causing asbestos‐like pleural lesions relevant to mesothelioma development.
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