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rubitecan

Known as: 9-Nitro-20 (S-)Camptothecin, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, (S)-isomer 
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Antineoplastic AgentsCamptothecinTopoisomerase I Inhibitors
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (2)

OrathecinRFS 2000

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Novel vitamin E analogue and 9-nitro-camptothecin administered as liposome aerosols decrease syngeneic mouse mammary tumor burden and inhibit metastasis
PurposeTo test the anticancer properties of a nonhydrolyzable ether-linked acetic acid analogue of vitamin E, 2,5,7,8-tetramethyl… 
Review
2002
Review
2002
Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.
The camptothecins are a maturing class of anticancer agents. In this article, we review the pharmacology and antitumor activity… 
Highly Cited
2001
Highly Cited
2001
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
Stimulation of CD95 leads to oligomerization of this receptor and the recruitment of the Fas-associated death domain (FADD) and… 
Highly Cited
1999
Highly Cited
1999
A study of 9-nitrocamptothecin (RFS-2000) in patients with advanced pancreatic cancer.
This ongoing study evaluates the efficacy of oral 9-nitrocamptothecin (9NC), or RFS-2000, in the treatment of advanced pancreatic… 
Highly Cited
1999
Highly Cited
1999
Anticancer exffect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice
Purpose: To test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9-NC) against… 
Highly Cited
1998
Highly Cited
1998
A phase I clinical and pharmacological study of oral 9-nitrocamptothecin, a novel water-insoluble topoisomerase I inhibitor
9-nitrocamptothecin (9NC) is a water-insoluble topoisomerase I inhibitor with a broad antitumor activity in animal models. To… 
Highly Cited
1998
Highly Cited
1998
Alkyl esters of camptothecin and 9-nitrocamptothecin: synthesis, in vitro pharmacokinetics, toxicity, and antitumor activity.
Eleven camptothecin esters, 6a-e and 7a-f, were prepared by straightforward acylation of camptothecins with the corresponding… 
Highly Cited
1996
Highly Cited
1996
Phase I Clinical and Pharmacological Studies of 20‐(S)‐Camptothecin and 20‐(S)‐9‐Nitrocamptothecin as Anticancer Agents
Groups of 52 and 29 patients with refractory cancers received either native camptothecin (CPT) or 9-nitrocamptothecin (9NC… 
Highly Cited
1993
Highly Cited
1993
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non‐tumorigenic and tumorigenic cells in vitro
We have recently shown that the plant alkaloid 20(S)‐camptothecin and its derivatives 9‐nitro‐20(S)‐camptothecin(9NC) and 9‐amino… 
Highly Cited
1992
Highly Cited
1992
Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins.
The plant alkaloid camptothecin and three camptothecin derivatives were used to study responses of human malignant melanoma (BRO… 
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