Skip to search formSkip to main contentSkip to account menu

rubitecan

Known as: 9-Nitro-20 (S-)Camptothecin, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, (S)-isomer 
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Antineoplastic AgentsCamptothecinTopoisomerase I Inhibitors
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (2)

OrathecinRFS 2000

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Study on Preparation of 9-Nitrocamptothecin Stealth Liposomes Composed of DPPC and SPC
  • Gu We
  • 2014
  • Corpus ID: 100998529
OBJECTIVE To investigate the preparing methods and process of 9-nitrocamptothecin(9-NC)stealth liposomes composed of HSPC and SPC… 
2012
2012
Relationship between lactone ratios of 9-nitrocamptothecin and their lactone/carboxylate equilibria in vitro and in vivo
2008
2008
Determination of 9-Nitrocamptothecin in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry
  • S. Jia
  • 2008
  • Corpus ID: 102206282
Aim To establish an HPLC-MS-MS method for the determination of 9-Nitrocamptothecin in human plasma.Methods Camptothecin was used… 
2008
2008
Preparation of 9-nitrocamptothecin self-emulsified microemulsion and its pharmacokinetics in rats
Objective To prepare the self-emulsified microemulsion of 9-nitrocamptothecin(9-NC SMEDDS) for intravenous injection and… 
2007
2007
Investigation of the effects of [alpha]-TEA, 9-nitrocamptothecin and paclitaxel alone and in combination on 66cl-4-GFP murine mammary cancer cells in vitro and in vivo
2005
2005
9-nitrocamptothecin,a new anti-tumor agent under development
9-nitrocamptothecin(9-NC) is a semi-synthetic derivative of camptothecin, acted by inhibition of DNA topoisomerase (Topo Ⅰ). 9-NC… 
2003
2003
Identification of the metabolites of 9-nitro-20(S)-camptothecin in rats.
9-Nitro-20(S)-camptothecin is a novel anticancer drug. In this study, metabolites of 9-nitro-20(S)-camptothecin in rats were… 
2003
2003
[Determination of 9-nitrocamptothecin in rat plasma and tissues by high performance liquid chromatography].
AIM To develop a sensitive, specific and accurate method for quantifying 9-nitrocamptothecin in rat plasma and tissues and to… 
2002
2002
Preclinical activity of an i.v. formulation of rubitecan in IDD-P™ against human solid tumor xenografts
An i.v. formulation of rubitecan (9-nitrocamptothecin) was evaluated in five human solid tumor xenograft models. Rubitecan in IDD… 
1994
1994
Development of resistance to 9‐nitro‐camptothecin by human leukemia U‐937 cells in vitro correlates with altered sensitivities to several anticancer drugs
We have recently reported that exposure of human leukemia U-937 calls to progressively Increasing concentrations of 9-nitro… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)