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rubitecan

Known as: 9-Nitro-20 (S-)Camptothecin, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, (S)-isomer 
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
This study was aimed at developing a polymeric drug delivery system for a new and potent antitumor drug, 9-nitrocamptothecin (9… Expand
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Highly Cited
2005
Highly Cited
2005
Drug treatment of colorectal cancer has made impressive progress during the past 10 years. In addition to the traditional 5… Expand
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Highly Cited
2004
Highly Cited
2004
Purpose: The purpose is to evaluate the feasibility and safety of aerosol administration of the topoisomerase I inhibitor, 9… Expand
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Highly Cited
2000
Highly Cited
2000
The response rates of relapsed osteosarcoma and melanoma pulmonary metastases to traditional i.v. chemotherapeutic regimens have… Expand
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Highly Cited
1999
Highly Cited
1999
This ongoing study evaluates the efficacy of oral 9-nitrocamptothecin (9NC), or RFS-2000, in the treatment of advanced pancreatic… Expand
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Highly Cited
1999
Highly Cited
1999
Purpose: To test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9-NC) against… Expand
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Review
1998
Review
1998
The camptothecin topoisomerase I-targeting agents are new class of antitumor drugs with demonstrated clinical activity in human… Expand
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Highly Cited
1998
Highly Cited
1998
9-nitrocamptothecin (9NC) is a water-insoluble topoisomerase I inhibitor with a broad antitumor activity in animal models. To… Expand
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Highly Cited
1994
Highly Cited
1994
Human U-937 myeloid leukemia cells were selected for resistance to increasing concentrations of the camptothecin derivative, 9… Expand
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Highly Cited
1992
Highly Cited
1992
The plant alkaloid camptothecin and three camptothecin derivatives were used to study responses of human malignant melanoma (BRO… Expand
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