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rubitecan

Known as: 9-Nitro-20 (S-)Camptothecin, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, (S)-isomer 
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme… 
National Institutes of Health

Papers overview

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Highly Cited
2020
Highly Cited
2020
Abstract In December 2019, COVID-19 epidemic was described in Wuhan, China, and the infection has spread widely affecting… 
Highly Cited
2005
Highly Cited
2005
Drug treatment of colorectal cancer has made impressive progress during the past 10 years. In addition to the traditional 5… 
Highly Cited
2004
Highly Cited
2004
Purpose: The purpose is to evaluate the feasibility and safety of aerosol administration of the topoisomerase I inhibitor, 9… 
Review
2002
Review
2002
The camptothecins are a maturing class of anticancer agents. In this article, we review the pharmacology and antitumor activity… 
Highly Cited
2000
Highly Cited
2000
The response rates of relapsed osteosarcoma and melanoma pulmonary metastases to traditional i.v. chemotherapeutic regimens have… 
Highly Cited
1999
Highly Cited
1999
This ongoing study evaluates the efficacy of oral 9-nitrocamptothecin (9NC), or RFS-2000, in the treatment of advanced pancreatic… 
Review
1998
Review
1998
Highly Cited
1992
Highly Cited
1992
The plant alkaloid camptothecin and three camptothecin derivatives were used to study responses of human malignant melanoma (BRO…