rubitecan

Known as: 9-Nitro-20 (S-)Camptothecin, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, (S)-isomer 
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme… (More)
National Institutes of Health

Papers overview

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2009
2009
In this study, folate-conjugated polymer micelles were synthesized by mixing folate-poly(ethylene glycol… (More)
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Review
2008
Review
2008
Regional chemotherapy has been proposed as a treatment modality in a number of cancer settings. In primary or metastatic lung… (More)
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2007
2007
This study was aimed at developing a polymeric drug delivery system for a new and potent antitumor drug, 9-nitrocamptothecin (9… (More)
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2004
2004
PURPOSE The purpose is to evaluate the feasibility and safety of aerosol administration of the topoisomerase I inhibitor, 9… (More)
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2000
2000
The response rates of relapsed osteosarcoma and melanoma pulmonary metastases to traditional i.v. chemotherapeutic regimens have… (More)
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1999
1999
PURPOSE To test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9-NC) against… (More)
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1999
1999
Purpose: The plant alkaloid camptothecin (CPT) has shown significant antitumor activity against a wide variety of human tumors… (More)
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Review
1998
Review
1998
The camptothecin topoisomerase I-targeting agents are new class of antitumor drugs with demonstrated clinical activity in human… (More)
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1996
1996
Groups of 52 and 29 patients with refractory cancers received either native camptothecin (CPT) or 9-nitrocamptothecin (9NC… (More)
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1994
1994
Human U-937 myeloid leukemia cells were selected for resistance to increasing concentrations of the camptothecin derivative, 9… (More)
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