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rubitecan

Known as: 9-Nitro-20 (S-)Camptothecin, 9-Nitro-20(S)-camptothecin, 9-nitrocamptothecin, (S)-isomer 
A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

Antineoplastic AgentsCamptothecinTopoisomerase I Inhibitors
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (2)

OrathecinRFS 2000

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Key role of topoisomerase I inhibitors in the treatment of recurrent and refractory epithelial ovarian carcinoma
Ovarian cancer remains one of the most difficult gynecologic cancers to treat, owing to its aggressive biology and high relapse… 
Highly Cited
2004
Highly Cited
2004
Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs.
Highly Cited
2002
Highly Cited
2002
Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan).
The purpose of this study is to establish the maximum tolerated dose of rubitecan in mice, dogs and men and to establish the… 
2002
2002
A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs.
We describe a versatile prodrug strategy for loading the liposomal lumen with water-insoluble camptothecins. The procedure… 
Highly Cited
2001
Highly Cited
2001
A phase II study of 9-nitrocamptothecin in patients with advanced pancreatic adenocarcinoma
Abstract.Purpose: Preclinical and phase I clinical data suggest that 9-nitrocamptothecin (9NC) is an agent with potential… 
Highly Cited
1999
Highly Cited
1999
A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer.
9-Nitrocamptothecin (9-NC) is a water-insoluble topoisomerase I inhibitor with a broad antitumor activity in animal models. A… 
1994
1994
Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro.
In a recent study, we showed that the plant alkaloid camptothecin (CPT) and its derivatives 9-nitro-CPT (9NC) and 9-amino-CPT… 
1994
1994
Therapeutic efficacy of camptothecin derivatives against human malignant melanoma xenografts
Camptothecin (CPT) and some of its derivatives are currently used in several clinical studies with patients bearing leukaemias… 
Highly Cited
1993
Highly Cited
1993
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non‐tumorigenic and tumorigenic cells in vitro
We have recently shown that the plant alkaloid 20(S)‐camptothecin and its derivatives 9‐nitro‐20(S)‐camptothecin(9NC) and 9‐amino… 
Highly Cited
1993
Highly Cited
1993
Efficacy of camptothecin congeners in the treatment of human breast carcinoma xenografts.
We have shown recently that the plant alkaloid camptothecin and some of its derivatives inhibit growth of human breast carcinoma… 
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