Topoisomerase I Inhibitors

Known as: Topoisomerase-I Inhibitor, Topoisomerase-I Inhibitors, Inhibitors, Topoisomerase 1 
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
024619932017

Papers overview

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2014
2014
We recently showed that poly(ADP-ribose) polymerase (PARP) inhibitors exert their cytotoxicity primarily by trapping PARP-DNA… (More)
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2014
2014
Aberrant expression of hedgehog molecules, particularly Gli1, is common in cancers of many tissues and is responsible for their… (More)
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2014
2014
Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer… (More)
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2012
2012
Poly(ADP-ribose) polymerase-1 (PARP1) plays critical roles in the regulation of DNA repair. Accordingly, small molecule… (More)
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2008
2008
The inhibition of DNA topoisomerase I (Top1) has proven to be a successful approach in the design of anticancer agents. However… (More)
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2004
2004
The hereditary prostate cancer 1 (HPC1) allele maps to the RNASEL gene encoding a protein (RNase L) implicated in the antiviral… (More)
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2002
2002
The expression of the death receptor Fas/CD95 is cell type-specific and can be modulated by different cytotoxic treatments. In… (More)
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1998
1998
We have previously shown that loss of p53 function in A2780 human ovarian adenocarcinoma cells confers increased clonogenic… (More)
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1998
1998
BACKGROUND SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11). Generally, topo-I… (More)
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1998
1998
The induction of apoptosis by topoisomerase I inhibitors, camptothecin and SN38, was evaluated in drug-sensitive HL60 and… (More)
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