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Topoisomerase I Inhibitors

Known as: Topoisomerase-I Inhibitor, Topoisomerase-I Inhibitors, Inhibitors, Topoisomerase 1 
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA… 
National Institutes of Health

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Narrower (25)

10,11-methylenedioxy-20-camptothecinACH 702BE 13793CCamptothecin
DNA Gyrase InhibitorsIn BloodTopoisomerase 1 Inhibitor [EPC]aspects of radiation effects

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Topoisomerase Inhibitors

Papers overview

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2013
2013
Abstract 5590: Screening of pediatric and adult sarcoma cell lines reveals novel patterns of sensitivity toward approved oncology drugs and investigational agents.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Sarcomas represent a heterogeneous group of… 
2012
2012
Chapter 2 EZN-2208 ( PEG-SN 38 ) overcomes ABCG 2-mediated topotecan resistance in BRCA 1-deficient mouse mammary tumors
BRCA1 dysfunction in hereditary breast cancer causes defective homology-directed DNA repair and sensitivity towards DNA damaging… 
2011
2011
OT3-01-14: N0937: Phase II Trial of Brostallicin and Cisplatin in Patients with Metastatic Triple Negative Breast Cancer.
Background Tumors that are negative for estrogen and progesterone receptors and do not over express HER2 are referred as “triple… 
Review
2004
Review
2004
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin: mechanism of resistance and clinical trials
The camptothecin derivative 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy camptothecin (CPT-11) has attracted the… 
1997
1997
Erratum: Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: Evidence for a protease-dependent pathway that does not activate cysteine protease 32 (Journal of Clinical…