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quinupristin

Known as: N-((6R,9S,10R,13S,15aS,18R,22S,24aS)-22-(p-(Dimethylamino)benzyl)-6-ethyldocosahydro-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-18-(((3S)-3-quinuclidinylthio)methyl)-12H-pyrido(2,1-f)pyrrolo(2,1-l)(1,4,7,10,13,16)oxapentaazacyclononadecin-9-yl)-3-hydroxypicolinamide, Virginiamycin S1, 4-(4-(dimethylamino)-N-methyl-L-phenylalanine)-5-(5-((1-azabicyclo(2.2.2)oct-3-ylthio)methyl)-4-oxo-L-2-piperidinecarboxylic Acid)-,(S)-, quinupristin [Chemical/Ingredient] 
A semi-synthetic derivative of pristinamycin, a natural occurring type B streptogramin. Quinupristin binds to the bacterial 50S ribosomal subunit… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Anti-Bacterial AgentsVirginiamycin
Bacterial InfectionsDecreased Protein Synthesis [PE]Drug AllergyProtein Synthesis Inhibitors [MoA]

Narrower (2)

RP 57669Synercid

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates.
Review
2008
Review
2008
New antibiotic agents for bloodstream infections.
Highly Cited
2007
Highly Cited
2007
LEADER surveillance program results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from the United States (50 medical centers).
Highly Cited
2006
Highly Cited
2006
Spectrum and potency of dalbavancin tested against 3322 Gram-positive cocci isolated in the United States Surveillance Program (2004).
2004
2004
Effect of prophylactic antibiotics on antimicrobial resistance of viridans streptococci in the normal flora of cataract surgery patients
Highly Cited
2004
Highly Cited
2004
Clinical-Use-Associated Decrease in Susceptibility of Vancomycin-Resistant Enterococcus faecium to Linezolid: a Comparison with Quinupristin-Dalfopristin
ABSTRACT The susceptibility of 135 vancomycin-resistant Enterococcus faecium bacteremic isolates to linezolid and quinupristin… 
Highly Cited
2002
Highly Cited
2002
Prevalence of esp, Encoding the Enterococcal Surface Protein, in Enterococcus faecalis and Enterococcus faecium Isolates from Hospital Patients, Poultry, and Pigs in Denmark
The enterococcal surface protein, Esp, originally found in Enterococcus faecalis , has been associated with increased virulence… 
Highly Cited
2001
Highly Cited
2001
Methicillin-Resistant, Quinupristin-Dalfopristin-Resistant Staphylococcus aureus with Reduced Sensitivity to Glycopeptides
ABSTRACT Of 3,052 Staphylococcus aureus strains collected by the European SENTRY surveillance study, 35 were found to be… 
Highly Cited
1998
Highly Cited
1998
Characterization of Vancomycin-Resistant Enterococcus faecium Isolates from the United States and Their Susceptibility In Vitro to Dalfopristin-Quinupristin
ABSTRACT In the course of clinical studies with the investigational streptogramin antimicrobial dalfopristin-quinupristin… 
Highly Cited
1998
Highly Cited
1998
Antipneumococcal Activities of a Ketolide (HMR 3647), a Streptogramin (Quinupristin-Dalfopristin), a Macrolide (Erythromycin), and a Lincosamide (Clindamycin)
ABSTRACT Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLSb) class of antimicrobial agents… 
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