Skip to search formSkip to main contentSkip to account menu

quinocarcin

Known as: 3,6-Imino-1H-2-oxa-11c-azanaphth(1,2,3-cd)azulene-5-carboxylic acid, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-, (2aalpha,3alpha,5alpha,6alpha,6aalpha,11balpha)-(-)-, quinocarmycin 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (3)

D 52KW 2152quinocarmycin citrate

Broader (1)

Isoquinolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Convergent synthesis of (-)-quinocarcin based on the combination of Sonogashira coupling and gold(I)-catalyzed 6-endo-dig hydroamination.
The total synthesis of the pentacyclic tetrahydroisoquinoline alkaloid quinocarcin, which possesses intriguing structural and… 
2013
2013
Radixin inhibition decreases adult neural progenitor cell migration and proliferation in vitro and in vivo
Neuronal progenitors capable of long distance migration are produced throughout life in the subventricular zone (SVZ). Migration… 
2008
2008
Analogs of Tetrahydroisoquinoline Natural Products That Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate-binding Site*
Cell migration is central to a number of normal and disease processes. Small organic molecules that inhibit cell migration have… 
2006
2006
Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44.
2005
2005
Synthesis of (−)-Quinocarcin by Directed Condensation of α-Amino Aldehydes
An enantioselective synthesis of the natural antiproliferative agent quinocarcin was achieved by the directed condensation of… 
Highly Cited
1996
Highly Cited
1996
1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin.
Leinamycin is a recently discovered, thiol-dependent DNA-cleaving natural product. The mechanism of DNA cleavage by leinamycin is… 
1990
1990
Synthesis and biological evaluation of quinocarcin derivatives.
Cyanation of quinocarcin readily opened the oxazolidine ring to provide DX-52-1 (2), which was a key compound in the synthesis of… 
1988
1988
Computer simulation of the binding of quinocarcin to DNA. Prediction of mode of action and absolute configuration
SummaryComputer-based models were derived for the covalent and noncovalent binding of the antitumor antibiotic quinocarcin to a… 
1988
1988
Antitumor activity of quinocarmycin (KW2152) against various cultured leukemia and lymphoma cell lines in vitro.
Growth inhibitory activity of quinocarmycin citrate (KW2152) against 25 human cultured cell lines derived from leukemias and… 
Highly Cited
1984
Highly Cited
1984
Quinocarcin, a novel antitumor antibiotic. 3. Mode of action.
Quinocarcin is a colorless antibiotic that was discovered in the culture broths of Streptomyces melanovinaceus.1) The structures… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)