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quinocarcin

Known as: 3,6-Imino-1H-2-oxa-11c-azanaphth(1,2,3-cd)azulene-5-carboxylic acid, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-, (2aalpha,3alpha,5alpha,6alpha,6aalpha,11balpha)-(-)-, quinocarmycin 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (3)

D 52KW 2152quinocarmycin citrate

Broader (1)

Isoquinolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Radixin inhibition decreases adult neural progenitor cell migration and proliferation in vitro and in vivo
Neuronal progenitors capable of long distance migration are produced throughout life in the subventricular zone (SVZ). Migration… 
2011
2011
1,3-dipolar cycloadditions from tricyclic hemiaminals. Synthesis of the quinocarcin core through catalyst-free generation of azomethine ylides.
The generation of azomethine ylides from the readily accessible hemiaminals 3 and 8 or from iminium salt 10 was studied… 
2008
2008
Analogs of Tetrahydroisoquinoline Natural Products That Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate-binding Site*
Cell migration is central to a number of normal and disease processes. Small organic molecules that inhibit cell migration have… 
2006
2006
Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44.
2006
2006
The dipolar cyclo­addition of methyl acrylate to 1,5,6‐trimethyl‐3‐oxidopyrazinium
5,6-Dimethyl­pyrazin-2-one reacts with iodo­methane to give a quaternary salt, deprotonation of which liberates a 3… 
1998
1998
Assay for the quinocarmycin analog DX-52-1 in human plasma using high-performance liquid chromatography with automated column switching and low wavelength ultraviolet detection.
1996
1996
Synthesis and cytotoxicity of natural (-)-quinocarcin and its related compounds
Abstract 
1990
1990
Synthesis of quinone derivatives of quinocarcin.
O-Demethyl-DX-52-1 (3a) was prepared from quinocarcin (1) in two steps (cyanation and O-demethylation). Upon treatment with Fremy… 
1988
1988
Antitumor activity of quinocarmycin (KW2152) against various cultured leukemia and lymphoma cell lines in vitro.
Growth inhibitory activity of quinocarmycin citrate (KW2152) against 25 human cultured cell lines derived from leukemias and… 
1988
1988
Computer simulation of the binding of quinocarcin to DNA. Prediction of mode of action and absolute configuration
SummaryComputer-based models were derived for the covalent and noncovalent binding of the antitumor antibiotic quinocarcin to a… 
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