Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
- T. Tamaoki, H. Nomoto, I. Takahashi, Y. Kato, M. Morimoto, F. Tomita
- Biology, ChemistryBiochemical and Biophysical Research…
- 13 March 1986
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.
- E. Kobayashi, H. Nakano, M. Morimoto, T. Tamaoki
- Biology, ChemistryBiochemical and Biophysical Research…
- 15 March 1989
Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.
- E. Kobayashi, K. Ando, T. Tamaoki
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 25 October 1989
A novel complex of calphostin (UCN-1028), which specifically inhibits protein kinase C (PKC) has been isolated from the culture broth of a fungi Cladosporium cladosporioides, showing cytotoxic activities against various tumor cells.
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
- S. Akinaga, K. Gomi, M. Morimoto, T. Tamaoki, M. Okabe
- Biology, ChemistryCancer Research
- 15 September 1991
Results imply that UCN-01 is a promising antitumor agent which has a novel mechanism(s), of action, which has some aberrations in cellular signal transduction.
Novel antitumor antibiotics, tetrocarcins.
- F. Tomita, T. Tamaoki, S. Ishii
- ChemistryJournal of antibiotics (Tokyo. )
- 1 June 1980
In vitro and in vivo hematopoietic effect of mutant human granulocyte colony-stimulating factor.
Results suggest that KW-2228 might show a superior in vivo hematopoietic effect to intact rhG-CSF due to its high specific activity to progenitor cells, and also because of its improved physicochemical, biologic, and pharmacokinetic stability in host animals.
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.
- I. Takahashi, Y. Saitoh, T. Tamaoki
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 April 1989
A new inhibitor of protein kinase C (PKC), UCN-01, was isolated from the culture broth of Streptomyces sp. N-126. We have found that this strain also produces UCN-02 which is a stereoisomer of…
Antitumor activity of a novel antitumor antibiotic, quinocarmycin citrate (KW2152).
- K. Fujimoto, T. Oka, M. Morimoto
- Medicine, BiologyCancer Research
- 15 March 1987
A novel antitumor antibiotic, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-3,6-imino-1H-2-oxa-11 c- azanaphth(1,2,3-cd)azulene-5-carboxylic acid monocitrate (quinocarmycin citrate; KW2152) was…
DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.
- M. Hara, I. Takahashi, H. Nakano
- BiologyJournal of antibiotics (Tokyo. )
- 25 February 1989
Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities.
- F. Tomita, T. Tamaoki, M. Morimoto, K. Fujimoto
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 December 1981
A group of antitumor antibiotics with a novel skeleton, trioxacarcins, was discovered in culture broths of actinomycete strain DO-45, which is active against Gram-positive bacteria and experimental murine tumors such as sarcoma 180 and leukemia P388.
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