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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.
Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca++dependent protein kinase (protein kinase C) from rat brain, with anExpand
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C.
The potent cytotoxic activity and antitumor activity of calphostin C might be due to the inhibition of protein kinase C, and thus it may be potentially useful for the therapeutic application. Expand
Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.
A novel complex of calphostin (UCN-1028), which specifically inhibits protein kinase C (PKC) has been isolated from the culture broth of a fungi Cladosporium cladosporioides, showing cytotoxic activities against various tumor cells. Expand
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
Results imply that UCN-01 is a promising antitumor agent which has a novel mechanism(s), of action, which has some aberrations in cellular signal transduction. Expand
Novel antitumor antibiotics, tetrocarcins.
UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.
A new inhibitor of protein kinase C (PKC), UCN-01, was isolated from the culture broth of Streptomyces sp. N-126. We have found that this strain also produces UCN-02 which is a stereoisomer ofExpand
DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.
Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities.
A group of antitumor antibiotics with a novel skeleton, trioxacarcins, was discovered in culture broths of actinomycete strain DO-45, which is active against Gram-positive bacteria and experimental murine tumors such as sarcoma 180 and leukemia P388. Expand
Characteristics of antiviral and anticellular activities of human recombinant interferon-gamma.
The results indicate that the characteristics of antiviral and anticellular activities of ReIFN-Gamma are somewhat different from those of other IFNs including IFN-gamma. Expand
Growth-inhibitory activity of recombinant human interferon-beta against cultured human cells.
Results indicate that the anticellular activity of ReIFN-beta was not essentially affected by deficiency of carbohydrate, and the species specificity of IFN- beta was not mediated by carbohydrate. Expand