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pyruvate dehydrogenase (acetyl-transferring) kinase

Known as: (pyruvate dehydrogenase (lipoamide))kinase, PDH kinase, pyruvate dehydrogenase kinase 
National Institutes of Health

Related topics

Related topics

12 relations
PDK1 genePDK2 genePDK3 gene

Narrower (7)

PDK1 protein, humanPDK4 protein, humanPdk1 protein, ratPdk2 protein, rat

Broader (2)

Protein KinasesProtein-Serine-Threonine Kinases

Papers overview

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2016
2016
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
BackgroundHypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are… 
Highly Cited
2016
Highly Cited
2016
Apigenin ameliorates hypertension-induced cardiac hypertrophy and down-regulates cardiac hypoxia inducible factor-lα in rats.
Apigenin is a natural flavonoid compound that can inhibit hypoxia-inducible factor (HIF)-1α expression in cultured tumor cells… 
Review
2014
Review
2014
The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady… 
Highly Cited
2014
Highly Cited
2014
Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells
The unique metabolism of breast cancer cells provides interest in exploiting this phenomenon therapeutically. Metformin, a… 
2013
2013
Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling
Dichloroacetate (DCA) is an inhibitor of pyruvate dehydrogenase kinase (PDK), and recently it has been shown as a promising… 
2010
2010
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
Aging presumably initiates shifts in substrate oxidation mediated in part by changes in insulin sensitivity. Similar shifts occur… 
Highly Cited
2008
Highly Cited
2008
Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
The heart adapts to changes in nutritional status and energy demands by adjusting its relative metabolism of carbohydrates and… 
Highly Cited
2008
Highly Cited
2008
Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats
A characteristic manifestation of sepsis is muscle lactate accumulation. This study examined any putative (causative) association… 
Highly Cited
2007
Highly Cited
2007
The STAT5A-Mediated Induction of Pyruvate Dehydrogenase Kinase 4 Expression by Prolactin or Growth Hormone in Adipocytes
The purpose of this study was to determine whether pyruvate dehydrogenase kinase (PDK)4 was expressed in adipocytes and whether… 
2006
2006
Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms.
Thyroid hormone regulates metabolism through transcriptional and posttranscriptional mechanisms. The integration of these… 
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