PDK1 gene

Known as: pyruvate dehydrogenase kinase 1, Pyruvate Dehydrogenase Kinase, Isozyme 1 Gene, PDK1 
This gene is involved in glucose metabolism.
National Institutes of Health

Papers overview

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2014
2014
Aberrant expression of Lin28 and let-7 has been observed in many human malignancies. However, its functions and underlying… (More)
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Highly Cited
2014
Highly Cited
2014
Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular anabolic requirements, thus potentially… (More)
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Highly Cited
2014
Highly Cited
2014
Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is attributed to its regulation of the cell… (More)
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Highly Cited
2013
Highly Cited
2013
In response to tenacious stress signals, such as the unscheduled activation of oncogenes, cells can mobilize tumour suppressor… (More)
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Highly Cited
2008
Highly Cited
2008
PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), and serum and… (More)
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2008
2008
IGF-II, a potent stimulator of cellular proliferation, differentiation, and development, regulates uterine function and conceptus… (More)
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Highly Cited
2007
Highly Cited
2007
Hypoxia is a pervasive microenvironmental factor that affects normal development as well as tumor progression. In most normal… (More)
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Highly Cited
2006
Highly Cited
2006
Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion… (More)
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Highly Cited
2006
Highly Cited
2006
The HIF-1 transcription factor drives hypoxic gene expression changes that are thought to be adaptive for cells exposed to a… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Protein kinase B (PKB) is activated by phosphorylation of Thr308 and of Ser473. Thr308 is phosphorylated by the 3… (More)
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