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PDK2 gene

Known as: PDHK2, pyruvate dehydrogenase kinase 2, PYRUVATE DEHYDROGENASE KINASE, ISOENZYME 2 
National Institutes of Health

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Related topics

2 relations
pyruvate dehydrogenase (acetyl-transferring) kinasepyruvate dehydrogenase kinase isoform 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Long term treatment with quercetin in contrast to the sulfate and glucuronide conjugates affects HIF1α stability and Nrf2 signaling in endothelial cells and leads to changes in glucose metabolism.
2016
2016
A Comparative Docking Studies of Dichloroacetate Analogues on Four Isozymes of Pyruvate Dehydrogenase Kinase in Humans
Introduction: The four Pyruvate dehydrogenase kinases (PDKs) that regulate the mammalian Pyruvate dehydrogenase complex (PDC) are… 
2008
2008
Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2*
PDHK2 is a mitochondrial protein kinase that phosphorylates pyruvate dehydrogenase complex, thereby down-regulating the oxidation… 
2008
2008
Allosteric coupling in pyruvate dehydrogenase kinase 2.
Mitochondrial pyruvate dehydrogenase kinase 2 (PDHK2) phosphorylates the pyruvate dehydrogenase multienzyme complex (PDC) and… 
Highly Cited
2005
Highly Cited
2005
Cloning of the Rat Pyruvate Dehydrogenase Kinase 4 Gene Promoter
The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-CoA in mitochondria and is a key regulatory… 
Highly Cited
2004
Highly Cited
2004
Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells.
Protein kinase Balpha (PKBalpha/Akt-1) is a key mediator of multiple signaling pathways involved in angiogenesis, cell… 
2004
2004
PDK1 is required for the hormonal signaling pathway leading to meiotic resumption in starfish oocytes.
2003
2003
Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.
Highly Cited
2001
Highly Cited
2001
Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats.
Fiber type specificity for expression of all three rat skeletal muscle pyruvate dehydrogenase kinase (PDK) isoforms (PDK1, 2, and… 
1997
1997
A translation frameshift mutation induced by a cytosine insertion in the polycystic kidney disease 2 gene (PDK2).
Mutations in the PKD2 gene on the long arm of chromosome 4 are responsible for approximately 15% of cases of polycystic kidney… 
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