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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top associationExpand
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Provenance semirings
We show that relational algebra calculations for incomplete databases, probabilistic databases, bag semantics and why-provenance are particular cases of the same general algorithms involving semirings. Expand
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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (aExpand
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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in additionExpand
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in aExpand
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A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
The proteins encoded by the classical HLA class I and class II genes in the major histocompatibility complex (MHC) are highly polymorphic and are essential in self versus non-self immune recognition.Expand
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Structure of the Vesicular Stomatitis Virus Nucleoprotein-RNA Complex
Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, andExpand
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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
Linkage disequilibrium (LD) mapping provides a powerful method for fine-structure localization of rare disease genes, but has not yet been widely applied to common disease. We sought to design aExpand
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Association between microdeletion and microduplication at 16p11.2 and autism.
BACKGROUND Autism spectrum disorder is a heritable developmental disorder in which chromosomal abnormalities are thought to play a role. METHODS As a first component of a genomewide associationExpand
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Processing XML streams with deterministic automata and stream indexes
We consider the problem of evaluating a large number of XPath expressions on a stream of XML packets. Expand
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