• Publications
  • Influence
Mechanisms and regulation of endothelial VEGF receptor signalling
A clear understanding of the tight and multi-level regulation of VEGFR2 signalling is key to successful therapeutic suppression or stimulation of vascular growth. Expand
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.
It is shown that ALK1 inhibits angiogenesis by cooperating with the Notch pathway during vascular morphogenesis that may be relevant to the pathogenesis of HHT vascular lesions. Expand
Pharmacological Treatment of Coronary Artery Disease With Recombinant Fibroblast Growth Factor-2: Double-Blind, Randomized, Controlled Clinical Trial
A single intracoronary infusion of rFGF2 does not improve exercise tolerance or myocardial perfusion but does show trends toward symptomatic improvement at 90 (but not 180) days. Expand
Syndecans: new kids on the signaling block.
New advances are focused on in understanding of syndecan-mediated cell signaling, which has been demonstrated the essential role in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. Expand
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate oxygen delivery.Expand
FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.
This study shows that disruption of baseline fibroblast growth factor signaling to the endothelium leads to a dramatic reduction in let-7 miRNA levels that increases expression of transforming growth factor (TGF)-β ligands and receptors and activation of TGF-β signaling, leading to endothelial-to-mesenchymal transition (Endo-MT). Expand
Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization
It is shown that PNX stimulates pulmonary capillary endothelial cells (PCECs) to produce angiocrine growth factors that induce proliferation of epithelial progenitor cells supporting alveolarization and VEGFR2 and FGFR1 activation in PCECs increases MMP14-dependent bioavailability of EGFR ligands to initiate and sustain alveologenesis. Expand
Endothelial-to-mesenchymal transition drives atherosclerosis progression.
Investigation of the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis demonstrates a link between loss of protective endothelial FGFR signaling, development of EndMT, and progression of Atherosclerosis. Expand
Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2
  • K. Bein, M. Simons
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 13 October 2000
Tissue culture and in vitro assays demonstrated that the presence of purified TSR and intact TSP1 resulted in inhibition of MMP activity, suggesting that the TSPs may inhibit M MP activity by preventing activation of the MMP2 and MMP9 zymogens. Expand
VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.
It is concluded that activation of the VEGF-mediated arterial morphogenesis cascade requires phosphorylation of the Y(1175) site that is dependent on trafficking of internalized VEGFR2 away from the plasma membrane via a synectin-myosin-VI complex. Expand