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PDK1 protein, human

Known as: PDK1 (pyruvate dehydrogenase kinase, isozyme 1), human, Pyruvate Dehydrogenase Kinase Isoform 1, Pyruvate Dehydrogenase Kinase, Isoenzyme 1 
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (436 aa, ~49 kDa) is encoded by the human PDK1 gene. This protein is involved in… Expand
National Institutes of Health

Papers overview

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Review
2004
Review
2004
The interaction of insulin and growth factors with their receptors on the outside surface of a cell, leads to the activation of… Expand
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Highly Cited
2002
Highly Cited
2002
PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK. To learn more about the roles of PDK1, we… Expand
Highly Cited
2001
Highly Cited
2001
PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3‐kinase‐dependent manner in response to insulin/growth… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND In animal cells, recruitment of phosphatidylinositol 3-kinase by growth factor receptors generates 3-phosphoinositides… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Protein kinase B (PKB) is activated by phosphorylation of Thr308 and of Ser473. Thr308 is phosphorylated by the 3… Expand
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Highly Cited
1999
Highly Cited
1999
The PtdIns(3,4,5)P3-dependent activation of protein kinase B (PKB) by 3-phosphoinositide-dependent protein kinases-1 and -2 (PDK1… Expand
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Highly Cited
1999
Highly Cited
1999
3-Phosphoinositide-dependent protein kinase-1 (PDK1) interacts stereoselectively with the d-enantiomer of PtdIns(3,4,5)P3 (KD 1.6… Expand
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Highly Cited
1998
Highly Cited
1998
Phosphorylation sites in members of the protein kinase A (PKA), PKG, and PKC kinase subfamily are conserved. Thus, the PKB kinase… Expand
Highly Cited
1998
Highly Cited
1998
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The activation of protein kinase B (PKB, also known as c-Akt) is stimulated by insulin or growth factors and results… Expand
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