PDK1 protein, human

Known as: PDK1 (pyruvate dehydrogenase kinase, isozyme 1), human, Pyruvate Dehydrogenase Kinase Isoform 1, Pyruvate Dehydrogenase Kinase, Isoenzyme 1 
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (436 aa, ~49 kDa) is encoded by the human PDK1 gene. This protein is involved in… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
In three-dimensional matrices cancer cells move with a rounded, amoeboid morphology that is controlled by ROCK-dependent… (More)
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Highly Cited
2002
Highly Cited
2002
PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK. To learn more about the roles of PDK1, we… (More)
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Highly Cited
2001
Highly Cited
2001
PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3-kinase-dependent manner in response to insulin/growth… (More)
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Highly Cited
2000
Highly Cited
2000
The multi-site phosphorylation of the protein kinase C (PKC) superfamily plays an important role in the regulation of these… (More)
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Highly Cited
1999
Highly Cited
1999
The PtdIns(3,4,5)P3-dependent activation of protein kinase B (PKB) by 3-phosphoinositide-dependent protein kinases-1 and -2 (PDK1… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND In animal cells, recruitment of phosphatidylinositol 3-kinase by growth factor receptors generates 3-phosphoinositides… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Protein kinase B (PKB) is activated by phosphorylation of Thr308 and of Ser473. Thr308 is phosphorylated by the 3… (More)
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Highly Cited
1999
Highly Cited
1999
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The activation of protein kinase B (PKB, also known as c-Akt) is stimulated by insulin or growth factors and results… (More)
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