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The interaction of insulin and growth factors with their receptors on the outside surface of a cell, leads to the activation of… Expand PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK. To learn more about the roles of PDK1, we… Expand PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3‐kinase‐dependent manner in response to insulin/growth… Expand BACKGROUND
In animal cells, recruitment of phosphatidylinositol 3-kinase by growth factor receptors generates 3-phosphoinositides… Expand BACKGROUND
Protein kinase B (PKB) is activated by phosphorylation of Thr308 and of Ser473. Thr308 is phosphorylated by the 3… Expand The PtdIns(3,4,5)P3-dependent activation of protein kinase B (PKB) by 3-phosphoinositide-dependent protein kinases-1 and -2 (PDK1… Expand 3-Phosphoinositide-dependent protein kinase-1 (PDK1) interacts stereoselectively with the d-enantiomer of PtdIns(3,4,5)P3 (KD 1.6… Expand Phosphorylation sites in members of the protein kinase A (PKA), PKG, and PKC kinase subfamily are conserved. Thus, the PKB kinase… Expand BACKGROUND
The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… Expand BACKGROUND
The activation of protein kinase B (PKB, also known as c-Akt) is stimulated by insulin or growth factors and results… Expand