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pyroglutamyl-histidyl-glycine

Known as: Pyr-His-Gly, pyro-Glu-His-Gly-OH, pGlu-His-Gly 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (5)

Antineoplastic AgentsAppetite DepressantsOligopeptidesPyrrolidonecarboxylic Acid
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analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1.
TRH (thyroliberin) is a tripeptide (pGlu-His-ProNH2) that signals via G protein-coupled receptors. Until recently, only a single… Expand
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1988
1988
An endogenous colon mitosis inhibitor and dietary calcium inhibit the increased colonic cell proliferation induced by cholic acid.
We have previously reported that a single intraperitoneal injection of the tripeptide pGlu-His-GlyOH (colon mitosis inhibitor… Expand
Highly Cited
1986
Highly Cited
1986
Delineation of a Particulate Thyrotropin‐Releasing Hormone‐Degrading Enzyme in Rat Brain by the Use of Specific Inhibitors of Prolyl Endopeptidase and Pyroglutamyl Peptide Hydrolase
Abstract: The degradation of thyrotropin‐releasing hormone in rat brain homogenates was studied in the presence of N… Expand
Highly Cited
1982
Highly Cited
1982
Increased plasma levels of thyroid hormones in a frog Rana ridibunda following intravenous administration of TRH.
The vena abdominalis of pentobarbital anesthetized frogs (Rana ridibunda) was cannulated for injection and blood sampling. After… Expand
Highly Cited
1981
Highly Cited
1981
Behavioural effects of central and peripheral injection of various analogues and metabolites of Thyrotropin Releasing Hormone (TRH)
Bilateral injection of 2 biologically stable analogues of TRH, CG3509 (orotyl-His-Pro-NH2; 5 μg) or CG3703 (6-methyl-5-oxo… Expand
1981
1981
Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability
TRH exerts both endocrinological and neuropharmacological actions. Two analogues of TRH, Pyr-His-Mep . NH2 (L-trans-3… Expand
1980
1980
Modification of the proline residue of TRH enhances biological activity and inhibits degradation.
An analogue of TRH with a modified proline residue (Pyr-His-MepNH2) has been synthesised and evaluated. In CNS, but not endocrine… Expand
Highly Cited
1979
Highly Cited
1979
Satietin: A highly potent anorexogenic substance in human serum
  • J. Knoll
  • Physiology & Behavior
  • 1979
    • Corpus ID: 41460163
Abstract A substance named satietin, capable of reducing food intake drastically in rats deprived of food for 96 hr, was… Expand
1973
1973
Serum prolactin and TSH: effects of nursing and pyroGlu-His-ProNH2 administration in postpartum women.
Abstract Nursing induced a marked increase (up to 10-fold) in serum prolactin, but it had no measurable effect on the… Expand
Highly Cited
1971
Highly Cited
1971
Synthetic TRF (thyrotropin releasing factor) analogues. II. pGlu-N3imMe-His-Pro-NH2: a synthetic analogue with specific activity greater than that of TRF2.
A series of synthetic analogues of TRF (thyrotropin releasing factor, pGlu-His-Pro-NH2) have been tested for biological activity… Expand
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