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A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
TLDR
A novel small molecule inhibitor of the β-catenin signaling pathway, JW55, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrases 2 (TNKS1/2), regulators of theβ-catanin destruction complex is identified. Expand
Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption.
TLDR
Consumption of several foods, including cereal products, wine, beer and pork, were to some minor degree related to high plasma levels of ochratoxin A, and correlation analysis of combinations of two or more food categories did not result in any statistically significant correlation. Expand
Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation.
TLDR
It is shown that, in early P cells (P0 and P1), P-granule partitioning is achieved primarily by their migration through the cytoplasm towards the site of formation of the germline daughter cell, where they are then deposited. Expand
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
TLDR
2 new small molecules are identified that specifically inhibit canonical Wnt pathway at the level of the destruction complex in human colorectal cancer cells and inhibited the growth of tumor cells in both a mouse xenograft model of CRC and in Apc(Min) mice. Expand
Comparison of estimated dietary intake of acrylamide with hemoglobin adducts of acrylamide and glycidamide.
TLDR
A significant positive correlation was found between the AA-Hb adduct concentration and the intake of chips/snacks and crisp bread and a method using solid-phase extraction and liquid chromatography with negative electrospray tandem mass spectrometric (MS/MS) detection for the determination of the HbAdducts as phenylthiohydantoin derivatives in human blood was developed. Expand
Urinary acrylamide metabolites as biomarkers for short-term dietary exposure to acrylamide.
TLDR
In a multiple linear regression analysis, the urinary excreted acrylamide metabolites correlated statistically significant with intake of aspartic acid, protein, starch and coffee, and consumption of citrus fruits correlated negatively with excretion of acryamide metabolites. Expand
The role of red and processed meat in colorectal cancer development: a perspective.
TLDR
There is a need for further studies on differences between white and red meat, between processed and whole red meat and between different types of processed meats, as potential health risks may not be the same for all products. Expand
Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development.
TLDR
It is proposed that MES-3 acts epigenetically to induce a germline state that is inherited through both meiosis and mitosis and that is essential for survival of the germline. Expand
Biomarkers of exposure to heterocyclic amines: approaches to improve the exposure assessment.
TLDR
The use of PhIP in hair as a biomarker of exposure is promising, but needs validation, using other methods of exposure assessment. Expand
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice
TLDR
It is suggested that PGE2 act through PKA to promote β-catenin nuclear translocation and tumor development in ApcMin/+ mice in vivo, indicating that the direct regulatory effect of PKA on β- cateninnuclear translocation is operative in intestinal cancer. Expand
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