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Commentary on Clinical Safety of Recombinant Human Parathyroid Hormone 1‐34 in the Treatment of Osteoporosis in Men and Postmenopausal Women
RECOMBINANT HUMAN parathyroid hormone 1-34 [rhPTH(1–34)], currently under the Food and Drug Administration (FDA) review for marketing approval as FORTEO (teriparatide injection [rDNA origin]), is aExpand
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Teriparatide [Human PTH(1‐34)]: 2.5 Years of Experience on the Use and Safety of the Drug for the Treatment of Osteoporosis
IN NOVEMBER 2002, the Food and Drug Administration (FDA) approved teriparatide (Forteo) for the treatment of osteoporosis. Teriparatide contains the first 34 amino acids of human PTH. We will use theExpand
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Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I.
Formation of new capillaries, a critical component of tissue growth and repair, is a recognized process in the development, formation, and remodeling of bone. Vascular endothelial growth factorExpand
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Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone.
Three clonal strains of epithelial cells were established from a transplantable rat pituitary tumor. These strains have been serially propagated for 14–25 months. They were subcultured every 2–3Expand
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Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay.
Abstract Medullary thyroid carcinoma was predicted correctly by means of radioimmunoassay of serum and urine calcitonin in 11 members of one family. An increased concentration of calcitonin in seru...
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Tumor necrosis factor-alpha (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism.
Recombinant human (h) and murine (m) tumor necrosis factor (TNF)-alpha stimulated bone resorption and the production of prostaglandin (PG) E2 in neonatal mouse calvaria in organ culture. InExpand
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Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.
The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroidExpand
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The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. An 18-year experience.
An important question facing physicians who care for families with multiple endocrine neoplasia type 2a is whether prospective screening to detect early abnormalities of the thyroid, parathyroid, orExpand
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Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation
GH(4)C(1) cells are a clonal strain of rat pituitary cells that synthesize and secrete prolactin and growth hormone. Chronic treatment (longer than 24 h) of GH(4)C(1) cells with epidermal growthExpand
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Relationship of thyrotropin-releasing hormone-induced spike and plateau phases in cytosolic free Ca2+ concentrations to hormone secretion. Selective blockade using ionomycin and nifedipine.
In clonal rat pituitary cells (GH cells), thyrotropin-releasing hormone (TRH) induced a pattern of changes in cytosolic free calcium concentrations [( Ca2+]i) composed of two phases: an acute spikeExpand
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