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Pyrrolidonecarboxylic Acid

Known as: 5-Oxo-L-Proline, 5-Carboxy-2-Pyrrolidinone, 5-Oxopyrrolidine-2-Carboxylic Acid 
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
National Institutes of Health

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50 relations

Narrower (43)

(S)-ethyl 4,4-dimethyl pyroglutamate9-fluoroenylmethoxycarbonylpyroglutamateFR 900148GnRH-III

Broader (1)

Glutamic Acid
In BloodPOVIDONE-IODINE 7.5 mg in 1 mL TOPICAL EMULSION [Provodine]agonistsanalogs & derivatives

Papers overview

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Highly Cited
2008
Highly Cited
2008
Chiral N-heterocyclic carbene catalyzed staudinger reaction of ketenes with imines: highly enantioselective synthesis of N-Boc beta-lactams.
N-heterocyclic carbenes (NHCs) were demonstrated to be efficient catalysts for the Staudinger reaction of ketenes with N-tosyl, N… 
Highly Cited
2006
Highly Cited
2006
Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.
We present here a definitive metabonomic analysis in order to detect novel biomarker and metabolite information, implicating… 
Highly Cited
1999
Highly Cited
1999
Production of Organic Acids and Amino Acids from Fish Meat by Sub‐Critical Water Hydrolysis
Fish meat was easily liquefied by hydrolysis under subcritical conditions without oxidants, and aqueous phase and water‐insoluble… 
Highly Cited
1995
Highly Cited
1995
Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).
The structure of the metalloproteinase and hemorrhagic toxin atrolysin C form d (EC 3.4.24.42), from the venom of the western… 
Highly Cited
1985
Highly Cited
1985
Primary structures of locust adipokinetic hormones II.
Adipokinetic hormones II from corpora cardiaca of the locusts Schistocerca gregaria and Locusta migratoria, respectively, have… 
Highly Cited
1983
Highly Cited
1983
An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in…
The degradation of thyroliberin (less than Glu-His-Pro-NH2) to its component amino acids by the soluble fraction of guinea pig… 
Highly Cited
1981
Highly Cited
1981
Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate.
5-Oxo-L-prolinase, the enzyme that catalyzes the conversion of 5-oxo-L-proline to L-glutamate coupled to the cleavage of ATP to… 
Highly Cited
1979
Highly Cited
1979
Partial primary structure of bacteriorhodopsin: sequencing methods for membrane proteins.
The sequence of 102 amino acid residues from the NH2 terminus and that of 39 amino acid residues from the COOH terminus of… 
Highly Cited
1978
Highly Cited
1978
A technique for the removal of pyroglutamic acid from the amino terminus of proteins using calf liver pyroglutamate amino peptidase.
Highly Cited
1976
Highly Cited
1976
Demonstration of pyroglutamylpeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts.
Using a radioimmunoassay method for thyrotropin-releasing hormone, the presence of thyrotropin-releasing hormone-metabolizing… 
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