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Host-Gut Microbiota Metabolic Interactions
A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health. Expand
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
The main NMR spectroscopic applications in modern metabolic research are summarized, and detailed protocols for biofluid and tissue sample collection and preparation are provided, including the extraction of polar and lipophilic metabolites from tissues. Expand
OPLS discriminant analysis: combining the strengths of PLS‐DA and SIMCA classification
The characteristics of the OPLS method have been investigated for the purpose of discriminant analysis (OPLS‐DA). We demonstrate how class‐orthogonal variation can be exploited to augmentExpand
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
(1999). 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica:Expand
Metabonomics: a platform for studying drug toxicity and gene function
Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process. Expand
Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. Expand
Impact of the gut microbiota on inflammation, obesity, and metabolic disease
Current knowledge about the mechanistic interactions between the gut microbiota, host energy metabolism, and the host immune system in the context of obesity and metabolic disease is discussed, with a focus on the importance of the axis that links gut microbes and host metabolic inflammation. Expand
Systems biology: Metabonomics
By measuring and mathematically modelling changes in the levels of products of metabolism found in biological fluids and tissues, metabonomics offers fresh insight into the effects of diet, drugs and disease. Expand
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
Multivariate statistical modeling of the spectra shows that the genetic predisposition of the 129S6 mouse to impaired glucose homeostasis and NAFLD is associated with disruptions of choline metabolism, and indicates that gut microbiota may play an active role in the development of insulin resistance. Expand
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
The implementation of the statistical total correlation spectroscopy (STOCSY) analysis method with supervised pattern recognition and particularly orthogonal projection on latent structure-discriminant analysis (O-PLS-DA) offers a new powerful framework for analysis of metabonomic data. Expand